Examinando 7.1 Incentivos para publicaciones indizadas por Título

Publicación

A new species of poison-dart frog (Anura: Dendrobatidae) from Manu Province, Amazon region of southeastern Peru, with notes on its natural history, bioacoustics, phylogenetics, and recommended conservation status

(Magnolia Press, 2017)

Serrano-Rojas S.J.

;

Whitworth A.

;

Villacampa J.

;

Von May R.

;

Gutiérrez R.C.

;

Padial J.M.

;

Chaparro J.C.

We describe and name a new species of poison-dart frog from the Amazonian slopes of the Andes in Manu Province, Madre de Dios Department, Peru; specifically within the Amarakaeri Communal Reserve and the buffer zone of Manu National Park. Ameerega shihuemoy sp. nov. is supported by a unique combination of characters: black dorsum with cream to light orange dorsolateral lines, blue belly reticulated with black, and the lack of axillary, thigh and calf flash marks. Within Ameerega, it shares the general appearance of A. altamazonica, A. boliviana, A. hahneli, A. ignipedis, A. petersi, A. picta, A. pongoensis, A. pulchripecta, A. simulans, A. smaragdina, and A. yungicola; each possessing a granular black to brown dorsum, a light labial bar, a conspicuous dorsolateral line running from the snout to the groin, and a metallic blue belly and underside of arms and hind limbs. From most of these species it can be distinguished by lacking flash marks on the axillae, thighs, and calves (absent in only A. boliviana and A. smaragdina, most A. petersi, and some A. pongoensis), by having bright cream to orange dorsolateral stripes (white, intense yellow, or green in all other species, with the exception of A. picta), and by its blue belly reticulated with black (bluish white and black in A. boliviana, green and blue with black marbling in A. petersi, and green and blue lacking black marbling in A. smaragdina). Its mating call also shows clear differences to morphologically similar species, with a lower note repetition rate, longer space between calls, and higher fundamental and dominant frequencies. Phylogenetic analyses based on the 16S mitochondrial rRNA fragment also support the distinctiveness of the new species and suggest that A. shihuemoy is most closely related to Ameerega macero, A. altamazonica, A. rubriventris, and two undescribed species (Ameerega sp. from Porto Walter, Acre, Brazil, and Ameerega sp. from Ivochote, Cusco, Peru). Genetically, the new species is most similar to the sympatric A. macero, from which it clearly differs in characteristics of its advertisement call and coloration. The new species is found near rocky streams during the dry season and near temporary water bodies during the rainy season. Tadpoles are found in lentic water along streams, or in shallow, slow-moving streams. Given its small geographic range, we recommend that A. shihuemoy should be considered 'Near threatened' (NT) according to IUCN Red List criteria. Copyright © 2017 Magnolia Press.

Publicación

A NEW SPECIES OF TELMATOBIUS WIEGMANN, 1834, FROM THE EASTERN CORDILLERA CENTRAL OF THE ANDES, PERU. (ANURA: TELMATOBIIDAE), WITH DESCRIPTION OF ITS TADPOLE, AND RANGE EXTENSION OF T. MENDELSONI DE LA RIVA ET AL., 2012

(Carnegie Museum of Natural History, 2016)

Ttito, A

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Landauro, CZ

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Venegas, PJ

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De la Riva, I

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Chaparro, JC

We describe adult specimens and tadpoles of a new species of Telmatobius Wiegmann, 1834, Telmatobius mantaro, from the central Cordillera of the Andes in Peru. Specimens were collected in humid lower montane forests and dry lower montane forests between 2240–3170 m elevation at the northern parts of the Departments of Huancavelica and Ayacucho. We also report a range extension of 262 km west of the type locality for Telmatobius mendelsoni De la Riva et al., 2012, which was found in sympatry with T. mantaro in Ayacucho. The new species has a snout–vent length of 48.9–55.8 mm in three adult males, and both sexes have tympanic membrane differentiated and tympanic annulus visible, a feature that distinguishes the new species from the majority of other Peruvian Telmatobius. We propose to assign the IUCN category Critically Endangered to this species because of its small area of distribution and its high likelihood of being infected by Batrachochytrium dendrobatidis.

Publicación

A Pan-Amazonian species delimitation: High species diversity within the genus Amazophrynella (Anura: Bufonidae)

(PeerJ Inc., 2018)

Rojas R.R.

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Fouquet A.

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Ron S.R.

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Hernández-Ruz E.J.

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Melo-Sampaio P.R.

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Chaparro J.C.

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Vogt R.C.

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Carvalho V.T.

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Pinheiro L.C.

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Avila R.W.

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Farias I.P.

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Gordo M.

;

Hrbek T.

The effect of carboxymethylation and NH4I incorporation on the molecular dynamics of carrageenan films was studied. Broadband Dielectric Spectroscopy (BDS) assessed the presence of α and β relaxation processes. The effect of NH4I content was analyzed using the Havriliak-Negami model and parameterizing the temperature dependence of the relaxation times according to the Vogel-Fulcher-Tammann-Hesse (VFTH) equation. The glass transition temperature was found to decrease with the increase of NH4I content. These results suggest that carboxymethylation and the salt doping treatment increase the molecular mobility of NH4+ ions, making the films suitable for the development of solid electrolytes for energy storage applications. © 2018, © 2018 Taylor & Francis Group, LLC.

Publicación

Adsorption of arsenite and arsenate on binary and ternary magnetic nanocomposites with high iron oxide content

(Elsevier, 2018)

Ramos Guivar J.A.

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Bustamante D. A.

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Gonzalez J.C.

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Sanches E.A.

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Morales M.A.

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Raez J.M.

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López-Muñoz M.-J.

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Arencibia A.

Bare maghemite nanoparticles (Nps), binary, and ternary magnetic nanocomposites made with titanium dioxide (TiO2) and graphene oxide (GO) were synthesized by a facile and cheap coprecipitation chemical route, and used as magnetic nanoadsorbents to remove arsenite (As(III)) and arsenate (As(V)) from water. The structural, morphological, magnetic and surface properties were analyzed by XRD, TEM microscopy, FTIR and Raman vibrational spectroscopy, Mössbauer technique and N2 adsorption-desorption measurements. It was found that materials were composed of maghemite nanoparticles with crystallites diameters varying from 9 to 13 nm for bare Nps, binary and ternary nanocomposites, with these nanocomposites having a high percentage of maghemite phase (80%). The presence of TiO2 and GO in the binary and ternary materials was also confirmed. All the samples were found to show magnetic properties and a slight porosity, with a specific surface area that increases up to 82 m2 /g when the metal oxides Nps were supported on GO. The aqueous arsenic adsorption performance was studied from kinetic and equilibrium point of view, and the pH adsorption capacity dependence was evaluated aiming to explain the adsorption mechanism. The three nanocomposites prepared in this work exhibit high adsorption capacity for arsenic species, with values of maximum adsorption capacity ranging from 83.1 to 110.4 mg/g for As(III) and from 90.2 to 127.2 mg/g for As(V) from bare to ternary nanocomposites, and can be fast separated with a permanent magnet of neodymium (Nd) in less than 10 min. Therefore, these nanosystems can be proposed as good adsorbents for both arsenic species from water.

Publicación

Antineutrino Charged-Current Reactions on Hydrocarbon with Low Momentum Transfer

(American Physical Society, 2018)

Gran R.

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Betancourt M.

;

Elkins M.

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Rodrigues P.A.

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Akbar F.

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Aliaga L.

;

Andrade D.A.

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Bashyal A.

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Bellantoni L.

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Bercellie A.

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Bodek A.

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Bravar A.

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Budd H.

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Vera G.F.R.C.

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Cai T.

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Carneiro M.F.

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Coplowe D.

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Da Motta H.

;

Dytman S.A.

;

Díaz G.A.

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Felix J.

;

Fields L.

;

Fine R.

;

Gallagher H.

;

Ghosh A.

;

Haider H.

;

Han J.Y.

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Harris D.A.

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Henry S.

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Jena D.

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Kleykamp J.

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Kordosky M.

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Le T.

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Leistico J.R.

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Lovlein A.

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Lu X.-G.

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Maher E.

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Manly S.

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Mann W.A.

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Marshall C.M.

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McFarland K.S.

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McGowan A.M.

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Messerly B.

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Miller J.

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Mislivec A.

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Morfín J.G.

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Mousseau J.

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Naples D.

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Nelson J.K.

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Nguyen C.

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Norrick A.

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Nuruzzaman

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Olivier A.

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Paolone V.

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Patrick C.E.

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Perdue G.N.

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Ramírez M.A.

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Ransome R.D.

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Ray H.

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Ren L.

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Rimal D.

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Ruterbories D.

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Schellman H.

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Salinas C.J.S.

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Su H.

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Sultana M.

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Falero S.S.

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Valencia E.

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Wolcott J.

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Wospakrik M.

;

Yaeggy B.

;

(MINERvA Collaboration)

We report on multinucleon effects in low momentum transfer (< 0.8 GeV=c) antineutrino interactions on plastic (CH) scintillator. These data are from the 2010–2011 antineutrino phase of the MINERvA experiment at Fermilab. The hadronic energy spectrum of this inclusive sample is well described when a screening effect at a low energy transfer and a two-nucleon knockout process are added to a relativistic Fermi gas model of quasielastic, Δ resonance, and higher resonance processes. In this analysis, model elements introduced to describe previously published neutrino results have quantitatively similar benefits for this antineutrino sample. We present the results as a double-differential cross section to accelerate the investigation of alternate models for antineutrino scattering off nuclei.

Publicación

Arachne-A web-based event viewer for MINERvA

(Elsevier B.V., 2012)

Tagg, N

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Brangham, J

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Chvojka, J

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Clairemont, M

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Day, M

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Eberly, B

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Felix, J

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Fields, L

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Gago, AM

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Gran, R

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Harris, DA

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Kordosky, M

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Lee, H

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Maggi, G

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Maher, E

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Mann, WA

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Marshall, CM

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McFarland, KS

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McGowan, AM

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Mislivec, A

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Mousseau, J

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Osmanov, B

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Osta, J

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Paolone, V

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Perdue, G

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Ransome, RD

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Ray, H

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Schellman, H

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Schmitz, DW

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Simon, C

;

Salinas, CJS

;

Tice, BG

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Walding, J

;

Walton, T

;

Wolcott, J

;

Zhang, D

;

Ziemer, BP

Neutrino interaction events in the detector are visually represented with a web-based tool called Arachne. Data are retrieved from a central server via AJAX, and client-side JavaScript draws images into the user's browser window using the draft HTML 5 standard. These technologies allow neutrino interactions to be viewed by anyone with a web browser, allowing for easy hand-scanning of particle interactions. Arachne has been used in to evaluate neutrino data in a prototype detector, to tune reconstruction algorithms, and for public outreach and education.

Publicación

Arachne-A web-based event viewer for MINERνA

(Elsevier B.V., 2012)

Tagg N.

;

Brangham J.

;

Chvojka J.

;

Clairemont M.

;

Day M.

;

Eberly B.

;

Felix J.

;

Fields L.

;

Gago A.M.

;

Gran R.

;

Harris D.A.

;

Kordosky M.

;

Lee H.

;

Maggi G.

;

Maher E.

;

Mann W.A.

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Marshall C.M.

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McFarland K.S.

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McGowan A.M.

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Mislivec A.

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Mousseau J.

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Osmanov B.

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Osta J.

;

Paolone V.

;

Perdue G.

;

Ransome R.D.

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Ray H.

;

Schellman H.

;

Schmitz D.W.

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Simon C.

;

Solano Salinas C.J.

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Tice B.G.

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Walding J.

;

Walton T.

;

Wolcott J.

;

Zhang D.

;

Ziemer B.P.

Neutrino interaction events in the MINERνA detector are visually represented with a web-based tool called Arachne. Data are retrieved from a central server via AJAX, and client-side JavaScript draws images into the users browser window using the draft HTML 5 "standard". These technologies allow neutrino interactions to be viewed by anyone with a web browser, allowing for easy hand-scanning of particle interactions. Arachne has been used in MINERνA to evaluate neutrino data in a prototype detector, to tune reconstruction algorithms, and for public outreach and education. © 2012 Published by Elsevier B.V.

Publicación

CD133 in breast cancer cells and in breast cancer stem cells as another target for immunotherapy

(Permanyer Publications, 2016)

Tume, L

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Paco, K

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Ubidia-Incio, R

;

Moya, J

Breast cancer consists of a heterogeneous group of tumors with different features, biology and treatments. Cancer stem cells (CSCs) have been associated with an aggressive cellular behavior, resistance to chemotherapy and radiotherapy in many types of neoplasms, and a strong correlation between prominin-1 (CD133) expression in cancer stem cells from different types of cancer exist. A discussion is presented on recent immunotherapeutic strategies that target CD133 in breast CSCs. Furthermore, it is suggested that immunotherapy targeting CD133 breast CSCs and/or in combination with other current treatments result in a better outcome. © 2016 Sociedad Mexicana de Oncología.

Publicación

Characterization of the gene sequence of the peptide transport protein (PepT1) in paiche Arapaima gigas fingerlings [Caracterización de la secuencia del gen de la proteín transportadora de péptidos (PepT1) en alevines de paiche Arapaima gigas]

(Universidad Nacional Mayor de San Marcos, 2019)

Toledo O.E.

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Castañeda A.E.

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Feria M.A.

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Masías P.

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Cueva M.

;

Motte E.

The aim of this study was to characterize the PepT1 of pirarucu Arapaima gigas through genomic and proteomic tools. A transcriptomic and proteomic analysis was made from sections of the intestine, spleen, liver and kidney of fingerlings. The transcriptomic analysis allowed obtaining two consensus sequences of 357 and 459 bp. Both fragments showed a high degree of homology (78 and 80%), mainly with nucleotide sequences coding for the PepT1 of Scleropages formosus of the same Order as A. gigas. The proteomic analysis by double mass spectrometry MALDI TOF/TOF allowed to identify 15 peptide sequences of PepT1 in pirarucu. In conclusion, PepT1 was partially characterized in the intestine of pirarucu, which could be used for further studies on the evaluation of its expression. © 2019 Universidad Nacional Mayor de San Marcos. All rights reserved.

Publicación

Chemical Composition, Tocopherol and Carotenoid Content of Seeds from Different Andean Lupin (Lupinus mutabilis) Ecotypes

(Springer, 2021)

Berru L.B.

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Glorio-Paulet P.

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Basso C.

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Scarafoni A.

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Camarena F.

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Hidalgo A.

;

Brandolini A.

Andean lupin (Lupinus mutabilis) seeds are appreciated for their high protein and lipid contents and have potential applications as ingredients in food, cosmetic, and pharmaceutical industries. Nevertheless, the information about the seed composition (especially in lipophilic antioxidants) of ecotypes from distinct cropping areas is currently limited. Thus, the aim of the present research was to assess the morphological characteristics, chemical composition, tocopherol and carotenoid contents of the seeds of 33 Andean lupin ecotypes from different Peruvian regions, along with three L. albus, one L. angustifolius and one L. luteus controls. Significant differences were noted among the Andean ecotypes for all analyzed features. The protein, lipid and ash contents were 32.0–46.9, 13.6–18.6 and 2.7–4.4 g/100 g dry matter (DM), respectively. The seeds were rich in tocopherols (172.1–249.8 mg/kg DM; γ-tocopherol was 98% of total tocols) and low in carotenoids (0.69–2.89 mg/kg DM). Debittering increased the tocopherol content (227.0–378.2 mg/kg DM), probably because of the soluble components loss, although the carotenoid concentration remained unchanged. The Andean lupins had higher protein, lipid and tocopherol contents than L. albus and L. angustifolius; the L. luteus values were within the L. mutabilis range. These results suggest that L. mutabilis harbors nutritional characteristics that are well suited to modern food trends. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

Publicación

Demonstration of communication using neutrinos

(World Scientific Publishing Co. Pte Ltd, 2012)

Stancil, DD

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Adamson, P

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Alania, M

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Aliaga, L

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Andrews, M

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Del Castillo, CA

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Bagby, L

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Alba, JLB

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Bodek, A

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Boehnlein, D

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Bradford, R

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Brooks, WK

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Budd, H

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Butkevich, A

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Caicedo, DAM

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Capista, DP

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Castromonte, CM

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Chamorro, A

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Charlton, E

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Christy, ME

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Chvojka, J

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Conrow, PD

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Danko, I

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Day, M

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Devan, J

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Downey, JM

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Dytman, SA

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Eberly, B

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Fein, JR

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Felix, J

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Fields, L

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Fiorentini, GA

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Gago, AM

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Gallagher, H

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Gran, R

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Grange, J

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Griffin, J

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Griffin, T

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Hahn, E

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Harris, DA

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Higuera, A

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Hobbs, JA

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Hoffman, CM

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Hughes, BL

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Hurtado, K

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Judd, A

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Kafka, T

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Kephart, K

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Kilmer, J

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Kordosky, M

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Kulagin, SA

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Kuznetsov, VA

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Lanari, M

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Le, T

;

Lee, H

;

Loiacono, L

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Maggi, G

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Maher, E

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Manly, S

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Mann, WA

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Marshall, CM

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Mcfarland, KS

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Mislivec, A

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Mcgowan, AM

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Morfin, JG

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Da Motta, H

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Mousseau, J

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Nelson, JK

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Niemiec-Gielata, JA

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Ochoa, N

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Osmanov, B

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Osta, J

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Palomino, JL

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Paradis, JS

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Paolone, V

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Park, J

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Pena, C

;

Perdue, G

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Lara, CEP

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Peterman, AM

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Pla-Dalmau, A

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Pollock, B

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Prokoshin, F

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Ransome, RD

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Ray, H

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Reyhan, M

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Rubinov, P

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Ruggiero, D

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Sands, OS

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Schellman, H

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Schmitz, DW

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Schulte, EC

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Simon, C

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Salinas, CJS

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Stefanski, R

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Stevens, RG

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Tagg, N

;

Takhistov, V

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Tice, BG

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Tilden, RN

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Velasquez, JP

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Vergalosova, I

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Voirin, J

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Walding, J

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Walker, BJ

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Walton, T

;

Wolcott, J

;

Wytock, TP

;

Zavala, G

;

Zhang, D

;

Zhu, LY

;

Ziemer, BP

Beams of neutrinos have been proposed as a vehicle for communications under unusual circumstances, such as direct point-to-point global communication, communication with submarines, secure communications and interstellar communication. We report on the performance of a low-rate communications link established using the NuMI beam line and the MINERvA detector at Fermilab. The link achieved a decoded data rate of 0.1 bits/sec with a bit error rate of 1% over a distance of 1.035 km, including 240 m of earth.

Publicación

Design, calibration, and performance of the MINERvA detector

(Pontificia Universidad Católica del Perú, 2014)

Aliaga L.

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Bagby L.

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Baldin B.

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Baumbaugh A.

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Bodek A.

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Bradford R.

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Brooks W.K.

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Boehnlein D.

;

Boyd S.

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Budd H.

;

Butkevich A.

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Martinez Caicedo D.A.

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Castromonte C.M.

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Christy M.E.

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Chvojka J.

;

Da Motta H.

;

Damiani D.S.

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Danko I.

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Datta M.

;

Devan J.

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Draeger E.

;

Dytman S.A.

;

Díaz G.A.

;

Eberly B.

;

Edmondson D.A.

;

Felix J.

;

Fields L.

;

Fiorentini G.A.

;

Flight R.S.

;

Gago A.M.

;

Gallagher H.

;

George C.A.

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Gielata J.A.

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Gingu C.

;

Gran R.

;

Grange J.

;

Grossman N.

;

Harris D.A.

;

Heaton J.

;

Higuera A.

;

Hobbs J.A.

;

Howley I.J.

;

Hurtado K.

;

Jerkins M.

;

Kafka T.

;

Kantner M.O.

;

Keppel C.

;

Kilmer J.

;

Kordosky M.

;

Krajeski A.H.

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Kumbartzki G.J.

;

Lee H.

;

Leister A.G.

;

Locke G.

;

Maggi G.

;

Maher E.

;

Manly S.

;

Mann W.A.

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Marshall C.M.

;

McFarland K.S.

;

McGivern C.L.

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McGowan A.M.

;

Mislivec A.

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Morfín J.G.

;

Mousseau J.

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Naples D.

;

Nelson J.K.

;

Niculescu G.

;

Niculescu I.

;

O'Connor C.D.

;

Ochoa N.

;

Olsen J.

;

Osmanov B.

;

Osta J.

;

Palomino J.L.

;

Paolone V.

;

Park J.

;

Perdue G.N.

;

Peña C.

;

Pla-Dalmau A.

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Rakotondravohitra L.

;

Ransome R.D.

;

Ray H.

;

Ren L.

;

Rubinov P.

;

Rude C.

;

Sassin K.E.

;

Schellman H.

;

Schmitz D.W.

;

Schneider R.M.

;

Schulte E.C.

;

Simon C.

;

Snider F.D.

;

Snyder M.C.

;

Solano Salinas C.J.

;

Tagg N.

;

Tice B.G.

;

Tilden R.N.

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Velásquez J.P.

;

Walton T.

;

Westerberg A.

;

Wolcott J.

;

Wolthuis B.A.

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Woodward N.

;

Wytock T.

;

Zavala G.

;

Zeng H.B.

;

Zhang D.

;

Zhu L.Y.

;

Ziemer B.P.

The skin is the largest organ of the body that protects it from the external environment. High- frequency ultra sound (HF-US) has been used to visualize the skin in depth and to diagnose some pathologies in dermatological applications. Quantitative ultrasound (QUS) includes several techniques that provide values of particular physical properties. In this thesis work, three QUS parameters are explained and used to characterize healthy skin through HF-US: attenuation coefficient slope (ACS), backscatter coefficient (BSC) and shear wave speed (SWS). They were estimated with the regularized spectral-log difference (RSLD) method, the reference phan- tom method, and the crawling wave sonoelastography method, respectively. All the three parameters were assessed in phantoms, ex vivo and in vivo skin. In calibrated phantoms, RSLD showed a reduc- tion of up to 93% of the standard deviation concerning the estimation with SLD, and BSC showed an agreement with the Faran’s theoretical curve. In gelatin-based phantoms, surface acoustic waves (SAWs) were estimated in two interfaces: solid-water and solid-US gel, which all owed corroborating SAWs presence and finding an empirical compensation factor when the coupling interface is US gel. A correction factor of 0:97 for SAW-to-shear was found to avoid underestimation in phantoms. Porcine thigh was calculated in the range from 8 to 27 MHz, where the ACS was 4:08 _+_0:43 dB cm -1 MHz-1 and BSC was in the range from 10 1 to 10° sr-1 _cm-1. Crawling wave sonoelastography method was applied for the vibration frequencies between 200 Hz and 800 Hz, where SWS was in the range from 4:6 m/sto9:1 m/s. In vivo ACS and BSC were assessed in the healthy forearm and thigh, whereas SWS only in the thigh. The average ACS in the forearm dermis was 2.07dB cm-1 _MHz-1, which is in close agreement with the literature. A significant difference (p < 0.05) was found between the ACS in the forearm dermis and the thigh dermis (average ACS of 2.54dB cm-1 _MHz-1). The BSC of the forearm and thigh dermis were in the range from 10 -1 to 10° sr-1 _cm-1, and in the range from 10-1 to 10° sr-1 _cm-1, respectively. The SWS in the thigh dermis was 2:4 _+_0:38 m/s for a vibration frequency of 200Hz, with an increasing trend as frequency increases. Results suggest that these QUS parameters have the potential to be used as a tool for in vivo skin characterization and show potential for future application in skin lesions.

Publicación

Determination of the threshold of nanoparticle behavior: Structural and electronic properties study of nano-sized copper

(Elsevier B.V., 2014)

Torres-Vega J.J.

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Medrano L.R.

;

Landauro C.V.

;

Rojas-Tapia J.

In the present work we determine the threshold of the nanoparticle behavior of copper nanoparticles by studying their structural and electronic properties. The studied nanoparticles contain from 13 to 8217 atoms and were obtained by molecular dynamics simulations using the Johnson potential for copper based on the embedded atom method. The results indicate that for small copper nanoparticles (o1000 atoms, 2.8 nm) the surface plays an important role in their physical properties. Whereas, for large nanoparticles (42000 atoms, 3.5 nm), with spherical-like external shape and large percentage of fcc-like local structure, this effect is negligible and their electronic character are similar to such expected in solid copper. Finally, it has also been shown that copper nanoparticles change their electronic character, from metallic to insulating, after increasing the strength of the chemical disorder.

Publicación

Development in C++ and python of a time structure Analysis Tool for particle beam analysis for the MINERvA Test beam experiment

(Universidad Nacional de Ingeniería, 2016)

Salazar Quiroz, Gerald Fernando

We present in this thesis the results of the design and programming of a temporal anal- ysis tool for experiment data MINERVA Test Beam (TbTaTool), which receives pions and electrons in the energy range corresponding to the end of the interactions of neutrinos energy states with MINERvA detector. The TbTaTool is independent, flexible and adapt- able to other contexts where we need to analyze the distribution of events over time, because it has separated datasets’ production from the tool itself. Our tool has been applied to the data (Run 2 and Run 3) that the experiment has obtained in MTest at Fer- milab, focusing on the variables of frequency of spill of the particles (MI’s spill frequency), duration of spill (MI’s spill duration) and the profile over time of packets corresponding to the delivery of the particles (time profile). Our calculations show 0.01% of difference for the frequency of spill of the particles and 9.34%, for the second variable, compared to the values indicated by the Fermilab’s Accelerators Division. Furthermore, this tool had set the basis for constructing a real time DAQ visualizator of the measurement process. Se presenta los resultados del diseño y programación de una herramienta de análisis temporal para los datos del experimento MINERvA Test Beam (TbTaTool), que recibe piones y electrones en el rango de energía correspondiente a los estados energéticos finales de las interacciones de neutrinos con el detector MINERvA. El TbTaTool es independiente, flexible y adaptable a otros contextos donde se quiera analizar la distribución de eventos respecto al tiempo. Nuestra herramienta ha sido aplicada a los datos (Run 2 y Run 3) que el experimento ha obtenido en el MTest en el Fermilab, enfocandonos en las variables de frecuencia de entrega de las partículas (MI’s spill frequency), duración de la entrega (MI’s spill duration) y el perfil en el tiempo de los paquetes correspondientes a la entrega de las partículas (Time Profile). Nuestros cálculos muestran un 0.01% de diferencia para la frecuencia de entrega de las partículas y 9.34%, para la segunda variable, frente a los valores indicados por la División de Aceleradores de Fermilab. Ademas esta herramienta ha establecido el fundamento para la construcción de visualizador del proceso de adquisición de datos en tiempo real.

Publicación

Direct Measurement of Nuclear Dependence of Charged Current Quasielasticlike Neutrino Interactions Using MINERvA

(American Physical Society, 2017)

Betancourt M.

;

Ghosh A.

;

Walton T.

;

Altinok O.

;

Bellantoni L.

;

Bercellie A.

;

Bodek A.

;

Bravar A.

;

Cai T.

;

Martinez Caicedo D.A.

;

Carneiro M.F.

;

Dytman S.A.

;

Díaz G.A.

;

Felix J.

;

Fields L.

;

Fine R.

;

Galindo R.

;

Gallagher H.

;

Ghosh A.

;

Golan T.

;

Gran R.

;

Harris D.A.

;

Higuera A.

;

Hurtado K.

;

Kiveni M.

;

Kleykamp J.

;

Le T.

;

Maher E.

;

Manly S.

;

Mann W.A.

;

Marshall C.M.

;

McFarland K.S.

;

McGivern C.L.

;

McGowan A.M.

;

Messerly B.

;

Miller J.

;

Mislivec A.

;

Morfín J.G.

;

Mousseau J.

;

Naples D.

;

Nelson J.K.

;

Norrick A.

;

Nuruzzaman

;

Patrick C.E.

;

Perdue G.N.

;

Ramírez M.A.

;

Ren L.

;

Rimal D.

;

Rodrigues P.A.

;

Ruterbories D.

;

Schellman H.

;

Sobczyk J.T.

;

Solano Salinas C.J.

;

Sánchez Falero S.

;

Valencia E.

;

Wolcott J.

;

Wospakrik M.

;

Yaeggy B.

Charged-current νμ interactions on carbon, iron, and lead with a final state hadronic system of one or more protons with zero mesons are used to investigate the influence of the nuclear environment on quasielasticlike interactions. The transferred four-momentum squared to the target nucleus, Q2, is reconstructed based on the kinematics of the leading proton, and differential cross sections versus Q2 and the cross-section ratios of iron, lead, and carbon to scintillator are measured for the first time in a single experiment. The measurements show a dependence on the atomic number. While the quasielasticlike scattering on carbon is compatible with predictions, the trends exhibited by scattering on iron and lead favor a prediction with intranuclear rescattering of hadrons accounted for by a conventional particle cascade treatment. These measurements help discriminate between different models of both initial state nucleons and final state interactions used in the neutrino oscillation experiments.

Publicación

Drug Discovery from Peruvian Medicinal Plants for the Treatment of Psychosis

(The FASEB Journal, 2017)

Tume, L

;

Gallo, C

;

Malaga-Trillo, E

;

Poletti, G

;

Rojas, R

;

Vaisberg, AJ

Background Schizophrenia is a severe mental disorder that affects approximately 1% of the population. The main symptom is psychosis in which thought and emotions are impaired. Current pharmacological treatments for schizophrenia are partially effective and its long term intake causes side effects. In Peru, native communities since ancient times have considered the psychosis like “madness” and they have treated it using preparations from natural products. The Peruvian traditional medicine is a potential source of drugs because its effectiveness, possible low side effects and they could be acting on different molecular mechanisms compared to the current drugs on the market. Aim In this work, as a part of drug discovery process, we tested compounds‐containing fractions from four ethanolic extracts (EEs) on psychosis animal model, mammalian cells and receptors altered in mental diseases. Methods We carried out the separation of compounds‐containing fractions from EEs 1, 2, 3 and 4 based on solubility using medium pressure liquid chromatography. The selection of each fraction was based on thin layer chromatography profile. These fractions were tested in mice treated with MK‐801 (N‐methyl D‐aspartate receptor antagonist) to induce psychosis‐like symptoms. We used the open field test (OFT) to measure the hyperactivity over a period of time and prepulse inhibition (PPI) test to measure the startle response. Cytotoxicity assays were performed in mammalian cells to determine the IC50 using the sulforhodamine B method. Moreover, we determined for the EEs, functional and binding assays on a panel of receptors altered in mental diseases. Results Four compounds‐containing fractions (A, B, C and D) were obtained for each EE. In behavioural tests, the fraction A, C and D of EE1, the fraction A and B of EE2 suppressed psychosis‐like symptoms in OFT (p <0.001) and PPI test. Fraction C and D of EE3 only showed an effect on PPI test and all fractions of EE4 were not active neither in the OFT nor in the PPI test. The IC50 for each EE was >0. 01563mg/ml. Finally, functional and binding assays indicates that the four EEs have an effect on serotonin, dopamine, glutamate, adenosine receptors. Conclusion We obtained potential antipsychotic compounds‐containing fractions as initial stage of drug discovery from four EE of medicinal plants used for the treatment psychotic‐like symptoms. The four EE has an effect on receptors altered in this disease suggesting an effect on signalling pathways altered in psychosis. Therefore, purification and structure elucidation of the active(s) molecule(s) will help us to better understanding of the molecular mechanism by which they are doing their antipsychotic effect. Support or Funding Information National Council of science of technology (CONCYTEC) through CIENCIACTIVA and Universidad Peruana Cayetano Heredia.

Publicación

Evaluation of a lens-free imager to facilitate tuberculosis diagnostics in MODS

(Churchill Livingstone, 2016)

Solis L.

;

Coronel J.

;

Rueda D.

;

Gilman R.H.

;

Sheen P.

;

Zimic M.

Tuberculosis (TB) control efforts are hampered by a mismatch in diagnostic technology. Lack of adequate early diagnostics and Multi-drug resistant (MDR) detection is a critical problem in control efforts. Alternate and novel diagnostic approaches are required, especially in low-resources settings where they are needed most. The Microscopic Observation Drug Susceptibility (MODS) assay is a cost-effective, highly sensitive, and specific method based on the detection of characteristic cording growth patterns of Mycobacterium tuberculosis (MTB), in microscopic examination of a liquid culture under an inverted microscope. By adding antimicrobials to the wells, MODS also determines antimicrobial susceptibility in both MDR and Extreme Drug Resistant (XDR) tuberculosis. The interpretation of a MODS culture performed in a 24 well plate, requires an extensive inspection over the entire surface to detect TB cords. This process requires significant time and effort from a trained microscopist. We evaluated a lens-free imager system, able to render microscopic images of live specimens, for the proof of principle to be used for MODS culture interpretation. The lens-free imager system is able to digitalize a 24-mm2 surface with approximately 40X magnification in a single capture. The evaluation of the lens-free imager found that it produced microscopic images that were adequate for MODS interpretation by a human expert. Compared to the average time that takes a microscopist to completely examine a MODS culture sample, the lens free imager notably reduced the time of inspection. Therefore, lens-free imager variants may constitute promising systems to aid in the diagnostics of tuberculosis, by simplifying and reducing the time of inspection and permitting automatization of MODS interpretation.

Publicación

Evidence for Neutral-Current Diffractive π0 Production from Hydrogen in Neutrino Interactions on Hydrocarbon

(American Physical Society, 2016)

Wolcott J.

;

Aliaga L.

;

Altinok O.

;

Bercellie A.

;

Betancourt M.

;

Bodek A.

;

Bravar A.

;

Budd H.

;

Cai T.

;

Carneiro M.F.

;

Chvojka J.

;

Da Motta H.

;

Devan J.

;

Dytman S.A.

;

Díaz G.A.

;

Eberly B.

;

Endress E.

;

Felix J.

;

Fields L.

;

Fine R.

;

Galindo R.

;

Gallagher H.

;

Golan T.

;

Gran R.

;

Harris D.A.

;

Higuera A.

;

Hurtado K.

;

Kiveni M.

;

Kleykamp J.

;

Kordosky M.

;

Le T.

;

Maher E.

;

Manly S.

;

Mann W.A.

;

Marshall C.M.

;

Martinez Caicedo D.A.

;

McFarland K.S.

;

McGivern C.L.

;

McGowan A.M.

;

Messerly B.

;

Miller J.

;

Mislivec A.

;

Morfín J.G.

;

Mousseau J.

;

Naples D.

;

Nelson J.K.

;

Norrick A.

;

Nuruzzaman

;

Osta J.

;

Paolone V.

;

Park J.

;

Patrick C.E.

;

Perdue G.N.

;

Rakotondravohitra L.

;

Ramirez M.A.

;

Ray H.

;

Ren L.

;

Rimal D.

;

Rodrigues P.A.

;

Ruterbories D.

;

Schellman H.

;

Schmitz D.W.

;

Solano Salinas C.J.

;

Sánchez Falero S.

;

Tagg N.

;

Tice B.G.

;

Valencia E.

;

Walton T.

;

Wospakrik M.

;

Zhang D.

The MINERvA experiment observes an excess of events containing electromagnetic showers relative to the expectation from Monte Carlo simulations in neutral-current neutrino interactions with mean beam energy of 4.5 GeV on a hydrocarbon target. The excess is characterized and found to be consistent with neutral-current π0 production with a broad energy distribution peaking at 7 GeV and a total cross section of 0.26 0.02ðstat.Þ 0.08ðsys:Þ × 10−39 cm2. The angular distribution, electromagnetic shower energy, and spatial distribution of the energy depositions of the excess are consistent with expectations from neutrino neutral-current diffractive π0 production from hydrogen in the hydrocarbon target. These data comprise the first direct experimental observation and constraint for a reaction that poses an important background process in neutrino-oscillation experiments searching for νμ to νe oscillations.

Publicación

Fascioliasis in schoolchildren in the inter andean valley of Cajamarca, Peru

(WAAVP 2015, 2015-08)

Rodríguez Ulloa, Claudia Rivera-Jacinto, Marco Hobán Vergara, Cristian Del Valle Mendoza, Juana Mercedes Ortiz Oblitas, Pedro

Fascioliasis, caused by Fasciola hepatica, is a public health problem in Peru, especially in schoolchildren. Prevalence rates in livestock are over 80% in dairy cattle reared in the Andean valley of Cajamarca, Peru. The present investigation aimed to determine the prevalence of F. hepatica infection in schoolchildren and the main risk factors involved in its presentation. Two hundred and seventy schoolchildren nine years old and over from primary public institutions from the district of Los Baños del Inca (Cajamarca) were included in the investigation. Questionnaires were applied to parents and children and fecal samples were taken and evaluated using the rapid sedimentation technique. Blood samples were also collected and analyzed. Seventeen fecal samples were positive to F. hepatica eggs, giving a prevalence of 6.3% (95% CI 3.21 - 9.38). Significant differences were found with origin of the child, history of intestinal parasitism, and the habit of chewing grass (p< 0.05). The rural origin (OR 4.8, 95% CI: 1.53-15.08) and the habit of chewing grass (OR 3.26, CI: 95% 1.07 - 9.96) were the most likely risk factors associated with the acquisition of infection. The leukocyte count of infected children varied between 3900 and 10580 cells /mm3 (mean ± SD = 6458.3 ± 2080.3). Thirty three percent of children positive to F. hepatica eggs presented eosinophilia. We conclude that the prevalence of human fascioliasis in the district of Los Baños del Inca is at the mesoendemic level and rurality provides conditions for acquiring the infection.

Publicación

Implementation of an alternative method to determine the critical cooling rate: Application in silver and copper nanoparticles

(Elsevier, 2014)

Medrano L.R.

;

Landauro C.V.

;

Rojas-Tapia J.

An alternative method to determine the critical cooling rate of materials has been developed by explaining the size and cooling rate dependences of physical properties of metallic nanoparticles through the scaling theory. This method has been applied to silver and copper nanoparticles which have been obtained by molecular dynamics simulations. The results reveal that our values for critical rate are close for each studied physical quantity. Thus, by taking the average among them, we obtain 6.2(8) × 1012 K/s for silver and 8.9(5) × 1012 K/s for copper. We have also found the threshold size of nanoparticle behavior is independent of the cooling rate.

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