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Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application

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dc.contributor.author Palomino-Durand C. es_PE
dc.contributor.author Lopez M. es_PE
dc.contributor.author Cazaux F. es_PE
dc.contributor.author Martel B. es_PE
dc.contributor.author Blanchemain N. es_PE
dc.contributor.author Chai F. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2019
dc.description This research was funded by FONDECYT–CONCYTEC (grant contract number 274-2015-FONDECYT).
dc.description.abstract Injectable pre-formed physical hydrogels provide many advantages for biomedical applications. Polyelectrolyte complexes (PEC) formed between cationic chitosan (CHT) and anionic polymers of cyclodextrin (PCD) render a hydrogel of great interest. Given the difference between water-soluble (PCDs) and water-insoluble PCD (PCDi) in the extension of polymerization, the present study aims to explore their impact on the formation and properties of CHT/PCD hydrogel obtained from the variable ratios of PCDi and PCDs in the formulation. Hydrogels CHT/PCDi/PCDs at weight ratios of 3:0:3, 3:1.5:1.5, and 3:3:0 were elaborated in a double⁻syringe system. The chemical composition, microstructure, viscoelastic properties, injectability, and structural integrity of the hydrogels were investigated. The cytotoxicity of the hydrogel was also evaluated by indirect contact with pre-osteoblast cells. Despite having similar shear⁻thinning and self-healing behaviors, the three hydrogels showed a marked difference in their rheological characteristics, injectability, structural stability, etc., depending on their PCDi and PCDs contents. Among the three, all the best above-mentioned properties, in addition to a high cytocompatibility, were found in the hydrogel 3:1.5:1.5. For the first time, we gained a deeper understanding of the role of the PCDi/PCDs in the injectable pre-formed hydrogels (CHT/PCDi/PCDs), which could be further fine-tuned to enhance their performance in biomedical applications.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.3390/polym11020214
dc.identifier.scopus 2-s2.0-85060655566
dc.identifier.uri https://hdl.handle.net/20.500.12390/659
dc.language.iso eng
dc.publisher MDPI AG
dc.relation.ispartof Polymers
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Watersoluble polymers
dc.subject Chitosan es_PE
dc.subject Cyclodextrins es_PE
dc.subject Functional polymers es_PE
dc.subject Medical applications es_PE
dc.subject Polyelectrolytes es_PE
dc.subject Shear flow es_PE
dc.subject Shear thinning es_PE
dc.subject Stability es_PE
dc.subject Viscoelasticity es_PE
dc.subject Injectable hydrogels es_PE
dc.subject Insoluble polymers es_PE
dc.subject Self-healing es_PE
dc.subject Viscoelastic properties es_PE
dc.subject Hydrogels es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.00.00
dc.title Influence of the soluble-insoluble ratios of cyclodextrins polymers on the viscoelastic properties of injectable chitosan-based hydrogels for biomedical application
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
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