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http://hdl.handle.net/20.500.12390/2843


Título: The genetic structure and adaptation of Andean highlanders and Amazonians are influenced by the interplay between geography and culture
Autor(es): Borda, Victor 
Alvim, Isabela 
Mendes, Marla 
Silva-Carvalho, Carolina 
Soares-Souza, Giordano B. 
Lear, Thiago P. 
Furlan, Vinicius 
Scliar, Marilia O. 
Zamudio, Roxana 
Zolini, Camila 
Araujo, Gilderlanio S. 
Luizon, Marcelo R. 
Padilla, Carlos 
Caceres, Omar 
Levano, Kelly 
Sanchez, Cesar 
Trujillo, Omar 
Flores-Villanueva, Pedro O. 
Dean, Michael 
Fuselli, Silvia 
Machado, Moara 
Romero, Pedro E. 
Tassi, Francesca 
Yeager, Meredith 
O'Connor, Timothy D. 
Gilman, Robert H. 
Tarazona-Santos, Eduardo 
Guio, Heinner 
Resumen: Western South America was one of the worldwide cradles of civilization. The well-known Inca Empire was the tip of the iceberg of an evolutionary process that started 11,000 to 14,000 years ago. Genetic data from 18 Peruvian populations reveal the following: 1) The between-population homogenization of the central southern Andes and its differentiation with respect to Amazonian populations of similar latitudes do not extend northward. Instead, longitudinal gene flow between the northern coast of Peru, Andes, and Amazonia accompanied cultural and socioeconomic interactions revealed by archeology. This pattern recapitulates the environmental and cultural differentiation between the fertile north, where altitudes are lower, and the arid south, where the Andes are higher, acting as a genetic barrier between the sharply different environments of the Andes and Amazonia. 2) The genetic homogenization between the populations of the arid Andes is not only due to migrations during the Inca Empire or the subsequent colonial period. It started at least during the earlier expansion of the Wari Empire (600 to 1,000 years before present). 3) This demographic history allowed for cases of positive natural selection in the high and arid Andes vs. the low Amazon tropical forest: in the Andes, a putative enhancer in HAND2-AS1 (heart and neural crest derivatives expressed 2 antisense RNA1, a noncoding gene related to cardiovascular function) and rs269868-C/Ser1067 in DUOX2 (dual oxidase 2, related to thyroid function and innate immunity) genes and, in the Amazon, the gene encoding for the CD45 protein, essential for antigen recognition by T and B lymphocytes in viral-host interaction.
Tema: Multidisciplinary
Editorial: Proceedings of the National Academy of Sciences
Fecha de publicación: 2020
Publicado en: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 
Financiamiento: 034-2019 
Tipo de publicación: info:eu-repo/semantics/article
Identificador Handle: http://hdl.handle.net/20.500.12390/2843
DOI: 10.1073/pnas.2013773117
Nivel de acceso: info:eu-repo/semantics/closedAccess
Colección:3.2 Pasantías y ponencias

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marcado en 20-oct-2021

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