Publicación:
Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis

Página de artículo simple
dc.contributor.author Jones E. es_PE
dc.contributor.author Pillay T.D. es_PE
dc.contributor.author Liu F. es_PE
dc.contributor.author Luo L. es_PE
dc.contributor.author Bazo-Alvarez J.C. es_PE
dc.contributor.author Yuan C. es_PE
dc.contributor.author Zhao S. es_PE
dc.contributor.author Chen Q. es_PE
dc.contributor.author Li Y. es_PE
dc.contributor.author Liao Q. es_PE
dc.contributor.author Yu H. es_PE
dc.contributor.author Rogier van Doorn H. es_PE
dc.contributor.author Sabanathan S. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2018
dc.description HRvD and SS were funded by the Wellcome Trust of Great Britain ( 089276/Z/09/Z and 106680/Z/14/Z ) and a Li Ka Shing Foundation–University of Oxford Global Health Program strategic award ( LG17 ). JCBA has been awarded a doctoral scholarship by CIENCIACTIVA, an initiative of the Peruvian National Council of Science, Technology and Technological Innovation (CONCYTEC); grant contract number 231-2015-FONDECYT. HY was supported by the National Science Fund for Distinguished Young Scholars ( No.81525023 ), the National Natural Science Foundation of China ( No. 81473031 ), the Li Ka Shing Oxford Global Health Programme ( No.B9RST00-B900.57 ).
dc.description.abstract Background. Hand, foot and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) is associated with acute neurological disease in children. This study aimed to estimate the burden of long-term sequelae and death following severe HFMD. Methods. This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015. Methods.This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015.Two independent reviewers assessed the literature.We used a random effects meta-analysis to estimate cumulative incidence of neurological sequelae or death. Studies were assessed for methodological and reporting quality. Findings. 43 studies were included in the review, and 599 children from 9 studies were included in the primary analysis. Estimated cumulative incidence of death or neurological sequelae at maximum follow up was 19.8% (95% CI:10.2%, 31.3%). Heterogeneity (Iˆ2) was 88.57%, partly accounted for by year of data collection and reporting quality of studies. Incidence by acute disease severity was 0.00% (0.00, 0.00) for grade IIa; 17.0% (7.9, 28.2) for grade IIb/III; 81.6% (65.1, 94.5) for grade IV (p = 0.00) disease.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.1016/j.ejpn.2018.04.007
dc.identifier.scopus 2-s2.0-85047211684
dc.identifier.uri https://hdl.handle.net/20.500.12390/728
dc.language.iso eng
dc.publisher W.B. Saunders Ltd
dc.relation.ispartof European Journal of Paediatric Neurology
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Embase
dc.subject Acute disease es_PE
dc.subject ataxia es_PE
dc.subject Cochrane Library es_PE
dc.subject disease severity es_PE
dc.subject dysphagia es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.00
dc.title Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis
dc.type info:eu-repo/semantics/review
dspace.entity.type Publication
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
Archivos
Colecciones
1.1 Eventos institucionales
 2.1 Estudios de doctorado y postdoctorado