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Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy

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dc.contributor.author Herrera-Calderon, Oscar es_PE
dc.contributor.author Yuli-Posadas, Ricado Ángel es_PE
dc.contributor.author Tinco-Jayo, Johnny Aldo es_PE
dc.contributor.author Enciso-Roca, Edwin es_PE
dc.contributor.author Franco-Quino, César es_PE
dc.contributor.author Chumpitaz-Cerrate, Victor es_PE
dc.contributor.author Figueroa-Salvador, Linder es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2019
dc.description The authors thank Universidad Nacional Mayor de San Marcos for helping to support this research. Cesar Franco-Quino is a doctoral student studying an Epidemiological Researcher Doctorate at Universidad Peruana Cayetano Heredia under FONDECYT/ CIENCIAACTIVA scholarship EF033-235-2015 and supported by training grant D43 TW007393 awarded by Fogarti International Center of the US National Institutes of Health.
dc.description.abstract Background: Experimental studies have demonstrated that fatty acids such as omega 3 and 6 have anti-inflammatory, anticonvulsant, cardio protective and anti-tumor effects. Objective:The main objective was to determine the protective effect of sacha inchi oil on pentylenetetrazole-induced seizures in albino mice. Material and Methods: Thirty male Balb/C albino mice of 8 weeks of age were purchased from the National Institute of Health (Lima-Peru). The animals were divided into 5 groups of 6 animals each one. Group I: Control; PTZ (pentylenetetrazole 80 mg / kg, s.c.). II: PTZ + Diazepam (1 mg / kg; s.c.). Group III, IV, V: PTZ + sacha inchi oil at single doses of 250, 500, 1000 mg / kg respectively orally. Sacha inchi oil was administered 30 minutes before induction of seizures by PTZ. Next, various parameters such as latency, seizure frequency, duration and score were scored according to Racine scale. The program Graph Pad Prism v.4 was used for statistical analysis. Results: As result, the experimental group treated with sacha inchi oil at maximum dose of 1000 mg/kg showed better results in response to PTZ induced seizure; low levels of seizures, frequency and duration (P<0.001; ANOVA, P <0.001 Post-hoc Dunnett test). Conclusion: It is concluded that Sacha inchi oil presented anticonvulsant effect at the highest doses tested being very similar to Diazepam. The main mechanism could be by reducing free radical and improving GABA levels in the brain. © 2019 Phcogj.Com.
dc.description.sponsorship Fondo Nacional de Desarrollo Científico y Tecnológico - Fondecyt
dc.identifier.doi https://doi.org/10.5530/PJ.2019.11.243
dc.identifier.scopus 2-s2.0-85077326578
dc.identifier.uri https://hdl.handle.net/20.500.12390/2746
dc.language.iso eng
dc.publisher EManuscript Technologies
dc.relation.ispartof Pharmacognosy Journal
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject Sacha inchi
dc.subject Convulsion es_PE
dc.subject Epilepsy es_PE
dc.subject Omega es_PE
dc.subject Pentylenetetrazole es_PE
dc.subject Plukenetia volubilis es_PE
dc.subject.ocde http://purl.org/pe-repo/ocde/ford#3.01.04
dc.title Neuroprotective effect of sacha inchi oil (Plukenetia volubilis L.) in an experimental model of epilepsy
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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