Validation of an Automated Cough Detection Algorithm for Tracking Recovery of Pulmonary Tuberculosis Patients

No hay miniatura disponible
Bravard, M
Comina, G
Gilman, RH
Larson, S
Lopez, JW
Tracey, BH
Título de la revista
Revista ISSN
Título del volumen
Public Library of Science
Proyectos de investigación
Unidades organizativas
Número de la revista
Background: A laboratory-free test for assessing recovery from pulmonary tuberculosis (TB) would be extremely beneficial in regions of the world where laboratory facilities are lacking. Our hypothesis is that analysis of cough sound recordings may provide such a test. In the current paper, we present validation of a cough analysis tool. Methodology/Principal Findings: Cough data was collected from a cohort of TB patients in Lima, Peru and 25.5 hours of recordings were manually annotated by clinical staff. Analysis software was developed and validated by comparison to manual scoring. Because many patients cough in bursts, coughing was characterized in terms of cough epochs. Our software correctly detects 75.5% of cough episodes with a specificity of 99.6% (comparable to past results using the same definition) and a median false positive rate of 4 false positives/hour, due to the noisy, real-world nature of our dataset. We then manually review detected coughs to eliminate false positives, in effect using the algorithm as a pre-screening tool that reduces reviewing time to roughly 5% of the recording length. This cough analysis approach provides a foundation to support larger-scale studies of coughing rates over time for TB patients undergoing treatment.
This work was funded in part by National Institutes of Health through awards 5D43TW006581 "Infectious Diseases Training Program in Peru'' and R21 AI094143 "Cough-A Rapid Indication of Response to Therapy in Pulmonary Tuberculosis''. JL and MB were supported by NIH Fogarty Foundation fellowships. G. Comina wants to thank the Consejo Nacional de Ciencia, Tecnologia e Innovacion Tecnologica of Peru (CONCYTEC) for their support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Palabras clave
Leicester, Cough, Bronchitis