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Functionalization of an alginate-based material by oxidation and reductive amination
Functionalization of an alginate-based material by oxidation and reductive amination
| dc.contributor.author | Huamani-Palomino R.G. | es_PE |
| dc.contributor.author | Córdova B.M. | es_PE |
| dc.contributor.author | Elvis Renzo Pichilingue L. | es_PE |
| dc.contributor.author | Venâncio T. | es_PE |
| dc.contributor.author | Valderrama A.C. | es_PE |
| dc.date.accessioned | 2024-05-30T23:13:38Z | |
| dc.date.available | 2024-05-30T23:13:38Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | This research focused on the synthesis of a functional alginate-based material via chemical modification processes with two steps: oxidation and reductive amination. In previous alginate functionalization with a target molecule such as cysteine, the starting material was purified and characterized by UV-Vis,1 H-NMR and HSQC. Additionally, the application of FT-IR techniques during each step of alginate functionalization was very useful, since new bands and spiked signals around the pyranose ring (1200–1000 cm−1) and anomeric region (1000–750 cm−1) region were identified by a second derivative. Additionally, the presence of C1-H1 of β-D-mannuronic acid residue as well as C1-H1 of α-L-guluronic acid residue was observed in the FT-IR spectra, including a band at 858 cm−1 with characteristics of the N-H moiety from cysteine. The possibility of attaching cysteine molecules to an alginate backbone by oxidation and post-reductive amination processes was confirmed through13 C-NMR in solid state; a new peak at 99.2 ppm was observed, owing to a hemiacetal group formed in oxidation alginate. Further, the peak at 31.2 ppm demonstrates the presence of carbon-CH2-SH in functionalized alginate—clear evidence that cysteine was successfully attached to the alginate backbone, with 185 µmol of thiol groups per gram polymer estimated in alginate-based material by UV-Visible. Finally, it was observed that guluronic acid residue of alginate are preferentially more affected than mannuronic acid residue in the functionalization. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | |
| dc.description.sponsorship | Fondo Nacional de Desarrollo Científico y Tecnológico - Fondecyt | |
| dc.identifier.citation | Huamani-Palomino, R. G., Córdova, B. M., Pichilingue L., E. R., Venâncio, T., & Valderrama, A. C. (2021). Functionalization of an Alginate-Based Material by Oxidation and Reductive Amination. Polymers, 13(2), 255. https://doi.org/10.3390/polym13020255 | |
| dc.identifier.doi | https://doi.org/10.3390/polym13020255 | |
| dc.identifier.scopus | 2-s2.0-85099877741 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12390/2409 | |
| dc.language.iso | eng | |
| dc.publisher | MDPI AG | |
| dc.relation.ispartof | Polymers | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Reductive amination | |
| dc.subject | Alginate | es_PE |
| dc.subject | Functionalization | es_PE |
| dc.subject | Oxidation | es_PE |
| dc.subject.ocde | http://purl.org/pe-repo/ocde/ford#1.04.01 | |
| dc.title | Functionalization of an alginate-based material by oxidation and reductive amination | |
| dc.type | info:eu-repo/semantics/article | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# |
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