Publicación:
Is exclusive breastfeeding for six-months protective against pediatric tuberculosis?
Is exclusive breastfeeding for six-months protective against pediatric tuberculosis?
No hay miniatura disponible
Fecha
2021
Autores
Flores, Juan A.
Coit, Julia
Mendoza, Milagros
Leon, Segundo R.
Konda, Kelika
Lecca, Leonid
Franke, Molly F.
Título de la revista
Revista ISSN
Título del volumen
Editor
Taylor and Francis Ltd.
Proyectos de investigación
Unidades organizativas
Número de la revista
Abstracto
Experts recommend exclusive breastfeeding from birth to six months because it protects against deadly childhood illness, including respiratory tract infections and diarrhea. We hypothesized that exclusive breastfeeding would decrease the risk of active tuberculosis (TB) in children. We analyzed cross-sectional data from 279 children in Lima, Peru aged 6 to 59 months with TB symptoms and a close adult contact with TB. Mothers self-reported breastfeeding, and children were evaluated for TB per national guidelines. To quantify the association between exclusive breastfeeding and TB, we estimated prevalence ratios using a generalized linear model with a log link, binomial distribution, and robust variance. Twenty-two percent of children were diagnosed with TB and 72% were exclusively breastfed for six months. We found no evidence that six months of exclusive breastfeeding was associated with TB disease in either bivariate analyses (prevalence ratio [PR] = 1.5; 95%CI = 0.8–2.5) or multivariable analyses adjusting for sex and socioeconomic status (adjusted PR = 1.6; 95%[CI] = 0.9–2.7). In post hoc analyses among children whose close TB contact was their mother, we found evidence of a weak positive association between breastfeeding and TB (aPR = 2.1; 95%[CI] = 0.9–4.9). This association was not apparent among children whose close contact was not the mother (aPR = 1.2; 95%[CI] = 0.6–2.4). Our results raise the possibility that children who are breastfed by mothers with TB may be at increased risk for TB, given the close contact. Due to the cross-sectional study design, these results should be interpreted with caution. If these findings are confirmed in longitudinal analyses, future interventions could aim to minimize TB transmission from mothers with TB to breastfeeding infants. © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Descripción
Palabras clave
risk factor,
breastfeeding,
child,
infant,
Mycobacterium tuberculosis