Publicación:
Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process
Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process
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Fecha
2018
Autores
Ccorahua R.
Moreno S.
Gumz H.
Sahre K.
Voit B.
Appelhans D.
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Revista ISSN
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Editor
Royal Society of Chemistry
Proyectos de investigación
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Abstracto
Reconstitution of biologically active polymersomes from the frozen or solid state into any fluid state is still
a challenging issue for the design of new biological experiments and for the formulation of therapeutic
agents. To gain knowledge about the reconstitution of pH-responsive and photo-crosslinked
polymersomes, surface-functionalized and enzyme-containing polymersomers were cryogenically
frozen ( 20 C) or freeze-dried with inulin as the lyoprotectant (0.1% w/v) and stored for a defined time
period. Reconstituting those polymersomes in solution by thawing or a re-dispersing process revealed
their original physical properties as well as their function as a pH-switchable enzymatic nanoreactor.
Descripción
Palabras clave
Therapeutic agents,
Biological experiments,
Cryogenic freezing,
Dispersing process,
Freeze-drying process,
Functionalized,
PH-responsive,
Polymersomes,
Functional polymers