Publicación:
Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers

Página de artículo simple
dc.contributor.author Ramos, AEF es_PE
dc.contributor.author Alcover, C es_PE
dc.contributor.author Maciuk, A es_PE
dc.contributor.author Duplais, C es_PE
dc.contributor.author Bernadat, G es_PE
dc.contributor.author Dejean, C es_PE
dc.contributor.author Jullian, JC es_PE
dc.contributor.author Grellier, P es_PE
dc.contributor.author Poupon, E es_PE
dc.contributor.author Evanno, L es_PE
dc.contributor.author Champy, P es_PE
dc.contributor.author Beniddir, MA es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2016
dc.description CONCYTEC is acknowledged for financing Alexander Fox's grant.
dc.description.abstract The approaches for the detection of natural products have evolved into more sophisticated ones thanks to the benefits of the big data era. In that context, a dereplication technique, called molecular networking, has been exploited by our team to undertake the phytochemical study of Geissospermum laeve (Vell.) Miers, a South American plant belonging to the Apocynceae family [1]. Applying this approach we sought the identification and isolation of minor compounds presenting original chemical structures. The molecular networking is based on the acquisition of chromatographic and spectral data by HPLC-ESI-Q/TOF, which then is displayed in the form of molecular networks of MS/MS fragmentation [2]. The application to the ethanolic extract from the stems of the plant allowed the identification and subsequent isolation of three new molecules, with a particularly original novel skeleton within the broad class of monoterpenoid indole alkaloids. Their isolation, structural elucidation, cytotoxicity and antiplasmodial activities are presented in this communication.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.1055/s-0036-1596203
dc.identifier.isi 411789300027
dc.identifier.uri https://hdl.handle.net/20.500.12390/1161
dc.language.iso eng
dc.publisher Thieme
dc.rights info:eu-repo/semantics/openAccess
dc.subject monoterpenoid indole alkaloid
dc.subject HPLC-ESI-Q/TOF es_PE
dc.subject molecular networking es_PE
dc.subject Geissospermum laeve es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.10
dc.title Unveiling the secrets of forgotten plants: Molecular networking-based phytochemical study of Geissospermum laeve (Vell.) Miers
dc.type info:eu-repo/semantics/conferenceObject
dspace.entity.type Publication
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
Archivos
Colecciones
1.1 Eventos institucionales
 2.1 Estudios de doctorado y postdoctorado