In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system Mogrovejo-Valdivia A. es_PE Rahmouni O. es_PE Tabary N. es_PE Maton M. es_PE Neut C. es_PE Martel B. es_PE Blanchemain N. es_PE 2024-05-30T23:13:38Z 2024-05-30T23:13:38Z 2019
dc.description This research was funded by FONDECYT-CONCYTEC (grant contract number 238-2015-FONDECYT). We want to acknowledge Dr Marco Lopez from INSERM U1008 for SEM analyses.
dc.description.abstract The goal of the study was to elaborate an antibacterial silver wound dressing covered by a protective coating that would prevent silver diffusion toward skin without losing its biocide properties. Therefore, non woven polyethyleneterephtalate (PET) textiles were pre-treated by two types of polysaccharides - chitosan and cyclodextrin - both crosslinked with citric acid by a pad/dry/cure process. Both types of resulting thermofixed textiles carrying the citrate crosslinks were then impregnated in silver solution followed by a thermal treatment and were finally coated by Layer-by-Layer (L-b-L) deposition of a polyelectrolyte multilayer (PEM) film consisting of anionic water-soluble poly-cyclodextrin and cationic chitosan. The influence of the process parameters was investigated in terms of silver adsorption capacity, PEM system build-up, silver kinetics of release and antibacterial activity. We demonstrate i) the utility of the intermediate thermal treatment step in the reduction of silver leakage in the polyelectrolyte solutions used in the L-b-L process, ii) that silver adsorption on the preliminary thermofixed layers did not affect the PEM system build-up, iii) the slowing down of silver release kinetic thanks to the PEM coating, iv) the preservation of the antibacterial activity despite the PEM coating.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.scopus 2-s2.0-85058800331
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof International Journal of Pharmaceutics
dc.rights info:eu-repo/semantics/openAccess
dc.subject silver derivative
dc.subject antiinfective agent es_PE
dc.subject chitosan es_PE
dc.subject citric acid es_PE
dc.subject cross linking reagent es_PE
dc.subject cyclodextrin es_PE
dc.subject polyelectrolyte es_PE
dc.subject chemistry es_PE
dc.subject drug effect es_PE
dc.title In vitro evaluation of drug release and antibacterial activity of a silver-loaded wound dressing coated with a multilayer system
dc.type info:eu-repo/semantics/article