Recurrence of Urinary Tract Infections due to Escherichia coli and Its Association with Antimicrobial Resistance Ormeno, Maria Angeles es_PE Ormeno, Maria Jose es_PE Quispe, Antonio M. es_PE Arias-Linares, Miguel Angel es_PE Linares, Elba es_PE Loza, Felix es_PE Ruiz, Joaquim es_PE Pons, Maria J. es_PE 2024-05-30T23:13:38Z 2024-05-30T23:13:38Z 2021
dc.description J.R. was supported by Fondo Nacional de Desarrollo Cientifico, Tecnologico y de Innovacion Tecnologica (FONDECYT-Peru) within the Proyecto de Mejoramiento y Ampliacion de los Servicios del Sistema Nacional de Ciencia, Tecnologia e Innovacion Tecnologica'' (contract: 08-2019-FONDECYT-BM-INC-INV).
dc.description.abstract We analyzed the association between antibiotic resistance and recurrent urinary tract infection (rUTI) by Escherichia coli. Susceptibility levels to 14 antimicrobial agents and the presence of extended-spectrum beta-lactamases (ESBL) were established using MicroScan. Incidences of multidrug resistant (MDR), extensively drug resistant (XDR), and ESBL-producer isolates as well as rUTIs were estimated. The time to recurrence was established adjusted for number of antibiotic-resistant families and MDR as predictors of interest, respectively. Overall, 8,553 urinary tract infection (UTI) cases related to E. coli, including 963 rITU, were analyzed with levels of resistance >30% in all cases, except for amikacin, nitrofurantoin, and carbapenems. The incidence of rUTI was of 11.3%, being 46.5%, 24.3%, and 42.5% for MDR, XDR, and ESBLs, respectively. Bivariate analysis showed that rUTI was associated with age, gender, resistance to specific antimicrobials, MDR, and XDR. The number of antibiotic families tested as resistant, MDR, XDR, gender, and age were associated with time to recurrence when adjusted for number of antibiotic families, and MDR, gender, and age were related when adjusted for MDR. High rates of antibiotic resistance to the usual antibiotics was observed in E. coli causing UTI, with female sex, age, and antibiotic resistance being risk factors for the development of rUTI.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.language.iso eng
dc.publisher MARY ANN LIEBERT, INC
dc.relation.ispartof MICROBIAL DRUG RESISTANCE
dc.rights info:eu-repo/semantics/openAccess
dc.subject urinary tract infection
dc.subject Escherichia coli es_PE
dc.subject recurrence es_PE
dc.subject antibiotic resistance es_PE
dc.subject multidrug resistance es_PE
dc.title Recurrence of Urinary Tract Infections due to Escherichia coli and Its Association with Antimicrobial Resistance
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication