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Recurrence of Urinary Tract Infections due to Escherichia coli and Its Association with Antimicrobial Resistance
Recurrence of Urinary Tract Infections due to Escherichia coli and Its Association with Antimicrobial Resistance
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Fecha
2021
Autores
Ormeno, Maria Angeles
Ormeno, Maria Jose
Quispe, Antonio M.
Arias-Linares, Miguel Angel
Linares, Elba
Loza, Felix
Ruiz, Joaquim
Pons, Maria J.
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MARY ANN LIEBERT, INC
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Abstracto
We analyzed the association between antibiotic resistance and recurrent urinary tract infection (rUTI) by Escherichia coli. Susceptibility levels to 14 antimicrobial agents and the presence of extended-spectrum beta-lactamases (ESBL) were established using MicroScan. Incidences of multidrug resistant (MDR), extensively drug resistant (XDR), and ESBL-producer isolates as well as rUTIs were estimated. The time to recurrence was established adjusted for number of antibiotic-resistant families and MDR as predictors of interest, respectively. Overall, 8,553 urinary tract infection (UTI) cases related to E. coli, including 963 rITU, were analyzed with levels of resistance >30% in all cases, except for amikacin, nitrofurantoin, and carbapenems. The incidence of rUTI was of 11.3%, being 46.5%, 24.3%, and 42.5% for MDR, XDR, and ESBLs, respectively. Bivariate analysis showed that rUTI was associated with age, gender, resistance to specific antimicrobials, MDR, and XDR. The number of antibiotic families tested as resistant, MDR, XDR, gender, and age were associated with time to recurrence when adjusted for number of antibiotic families, and MDR, gender, and age were related when adjusted for MDR. High rates of antibiotic resistance to the usual antibiotics was observed in E. coli causing UTI, with female sex, age, and antibiotic resistance being risk factors for the development of rUTI.
Descripción
J.R. was supported by Fondo Nacional de Desarrollo Cientifico, Tecnologico y de Innovacion Tecnologica (FONDECYT-Peru) within the Proyecto de Mejoramiento y Ampliacion de los Servicios del Sistema Nacional de Ciencia, Tecnologia e Innovacion Tecnologica'' (contract: 08-2019-FONDECYT-BM-INC-INV).
Palabras clave
urinary tract infection,
Escherichia coli,
recurrence,
antibiotic resistance,
multidrug resistance