Synthesis of highly stable κ/ι-hybrid carrageenan micro- and nanogels via a sonication-assisted microemulsion route

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Rodriguez S.
Torres F.G.
Arroyo J.
Gonzales K.N.
Troncoso O.P.
López D.
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SAGE Publications Ltd
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Novel carrageenan micro- and nanogels were developed via a sonication-assisted microemulsion processing route. The diameter of the dry samples ranged 197.3 −421.35 nm whereas the diameter of the samples suspended in water ranged 467.8–605.9 nm. Hybrid κ/ι-carrageenan, rather than κ- or ι-carrageenan was used for the first time for the preparation of micro- and nanogels. KCl was used as a cross-linking agent and Tween 80 was used as surfactant. The micro- and nanogels suspended in water were found to simultaneously exhibit a lower diameter, and a lower swelling ratio with higher Tween 80 content. The micro- and nanogel suspension yields a zeta potential value of −50.5 mV, superior to values reported elsewhere for pure κ- or ι-carrageenan micro- and nanogels. The high stability was attributed to the high hydrophile-lipophile balance (HLB = 15) value of Tween 80. These results suggest that hybrid κ/ι-carrageenan micro- and nanogels are promising candidates for smart therapeutics applications. © The Author(s) 2020.
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Council of Science, Technology and Technological Innovation [CONCYTEC-FONDECYT]; and the Vice-Rectorate for Research of the Pontificia Universidad Catolica del Peru [VRI-PUCP].
Palabras clave
sonication, Hybrid carrageenan, micro- and nanogels, microemulsion