Publicación:
Serum Insulin-Like Growth Factor I Deficiency Associates to Alzheimer's Disease Co-Morbidities
Serum Insulin-Like Growth Factor I Deficiency Associates to Alzheimer's Disease Co-Morbidities
No hay miniatura disponible
Fecha
2019
Autores
Zegarra-Valdivia, JA
Santi, A
de Sevilla, MEF
Nunez, A
Aleman, IT
Título de la revista
Revista ISSN
Título del volumen
Editor
IOS Press, Inc.
Proyectos de investigación
Unidades organizativas
Número de la revista
Abstracto
Increasing evidence supports the notion that Alzheimer's disease (AD), a condition that presents heterogeneous pathological disturbances, is also associated to perturbed metabolic function affecting insulin and insulin-like growth factor I (IGF-I). While impaired insulin activity leading to insulin resistance has been associated to AD, whether altered IGF-I function affects the disease is not entirely clear. Despite the limitations of mouse models to mimic AD pathology, we took advantage that serum IGF-I deficient mice (LID mice) present many functional perturbations present in AD, most prominently cognitive loss, which is reversed by treatment with systemic IGF-I. We analyzed whether these mice display other pathological traits that are usual co-morbidities of AD. We found that LID mice not only display cognitive disturbances, but also show altered mood and sociability, increased susceptibility to epileptiform activity, and a disturbed sleep/wake cycle. Collectively, these data suggest that reduced IGF-I activity contributes to heterogeneous deficits commonly associated to AD. We suggest that impaired IGF-I activity needs to be taken into consideration when modeling this condition.
Descripción
We are thankful to M. Garcia for technical support. This work was funded by a grant from Ciberned, by and Inter-CIBER project (PIE14/00061), and from SAF2016-76462-C2-1-P (MINECO). J.A. ZegarraValdivia acknowledges the financial support from the National Council of Science, Technology and Technological Innovation (CONCYTEC, Peru) through ´the National Fund for Scientific and Technological Development (FONDECYT, Peru). ´Authors’ disclosures available online (https://www.j-alz.com/manuscript-disclosures/19-0241).
Palabras clave
insulin-like growth factor 1,
Alzheimer’s disease,
animal models of disease,
co-morbidities