Publicación:
Oxfendazole flukicidal activity in pigs

Página de artículo simple
dc.contributor.author Ortiz P. es_PE
dc.contributor.author Terrones S. es_PE
dc.contributor.author Cabrera M. es_PE
dc.contributor.author Hoban C. es_PE
dc.contributor.author Ceballos L. es_PE
dc.contributor.author Moreno L. es_PE
dc.contributor.author Canton C. es_PE
dc.contributor.author Donadeu M. es_PE
dc.contributor.author Lanusse C. es_PE
dc.contributor.author Alvarez L. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2014
dc.description.abstract Although oxfendazole (OFZ) is a well know broad-spectrum benzimidazole anthelmintic, the assessment of its potential trematodicidal activity remains unexplored. OFZ administration at single high doses has been recommended to control Taenia solium cysticercus in pigs. The current study investigated the flukicidal activity obtained after a single high (30 mg/kg) oral dose of OFZ in pigs harbouring a natural Fasciola hepatica infection. Sixteen (16) local ecotype pigs were randomly allocated into two (2) experimental groups of 8 animals each named as follow: Untreated control and OFZ treated, in which animals received OFZ (Synanthic®, Merial Ltd., 9.06% suspension) orally at 30 mg/kg. At seven (7) days post-treatment, all the animals were sacrificed and direct adult liver fluke counts were performed following the WAAVP guidelines. None of the animals involved in this experiment showed any adverse event during the study. OFZ treatment as a single 30 mg/kg oral dose showed a 100% efficacy against F. hepatica. In conclusion, the trial described here demonstrated an excellent OFZ activity against F. hepatica in naturally infected pigs, after its administration at a single oral dose of 30 mg/kg. en
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.1016/j.actatropica.2014.03.024
dc.identifier.scopus 2-s2.0-84899653120
dc.identifier.uri https://hdl.handle.net/20.500.12390/729
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Acta Tropica
dc.rights info:eu-repo/semantics/openAccess
dc.subject pig
dc.subject oxfendazole es_PE
dc.subject anthelmintic agent es_PE
dc.subject benzimidazole derivative es_PE
dc.subject oxfendazole es_PE
dc.subject dose-response relationship es_PE
dc.subject dose-response relationship es_PE
dc.subject efficiency measurement es_PE
dc.subject infectivity es_PE
dc.subject parasite control es_PE
dc.subject parasitic disease es_PE
dc.subject absence of side effects es_PE
dc.subject adult es_PE
dc.subject adult es_PE
dc.subject animal experiment es_PE
dc.title Oxfendazole flukicidal activity in pigs
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
Archivos
Colecciones
1.1 Eventos institucionales
 7.1 Incentivos para publicaciones indizadas