Publicación:
Oxfendazole flukicidal activity in pigs
Oxfendazole flukicidal activity in pigs
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Fecha
2014
Autores
Ortiz P.
Terrones S.
Cabrera M.
Hoban C.
Ceballos L.
Moreno L.
Canton C.
Donadeu M.
Lanusse C.
Alvarez L.
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Editor
Elsevier
Proyectos de investigación
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Abstracto
Although oxfendazole (OFZ) is a well know broad-spectrum benzimidazole anthelmintic, the assessment
of its potential trematodicidal activity remains unexplored. OFZ administration at single high doses has
been recommended to control Taenia solium cysticercus in pigs. The current study investigated the flukicidal activity obtained after a single high (30 mg/kg) oral dose of OFZ in pigs harbouring a natural Fasciola
hepatica infection. Sixteen (16) local ecotype pigs were randomly allocated into two (2) experimental
groups of 8 animals each named as follow: Untreated control and OFZ treated, in which animals received
OFZ (Synanthic®, Merial Ltd., 9.06% suspension) orally at 30 mg/kg. At seven (7) days post-treatment, all
the animals were sacrificed and direct adult liver fluke counts were performed following the WAAVP
guidelines. None of the animals involved in this experiment showed any adverse event during the study.
OFZ treatment as a single 30 mg/kg oral dose showed a 100% efficacy against F. hepatica. In conclusion,
the trial described here demonstrated an excellent OFZ activity against F. hepatica in naturally infected
pigs, after its administration at a single oral dose of 30 mg/kg.
Descripción
Palabras clave
pig,
oxfendazole,
anthelmintic agent,
benzimidazole derivative,
oxfendazole,
dose-response relationship,
dose-response relationship,
efficiency measurement,
infectivity,
parasite control,
parasitic disease,
absence of side effects,
adult,
adult,
animal experiment