Publicación:
Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples
Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples
| dc.contributor.author | Lopez, Rosario | es_PE |
| dc.contributor.author | Khan, Sabir | es_PE |
| dc.contributor.author | Wong, Ademar | es_PE |
| dc.contributor.author | Sotomayor, Maria del Pilar Taboada | es_PE |
| dc.contributor.author | Picasso, Gino | es_PE |
| dc.date.accessioned | 2024-05-30T23:13:38Z | |
| dc.date.available | 2024-05-30T23:13:38Z | |
| dc.date.issued | 2021 | |
| dc.description | This project was supported by FONDECYT-BM (grant #0232019-FONDECYT-BM-IN.INV), FAPESP (grants #2019/006777 and #2014/50945-4), CNPq (grants #301728/2019-4, #408050/2018-7 and #465571/2014-0), and CAPES (PROJ. AUX/PE/PROEX N. 0674/2018). RL and GP received financial support from the OGI, Research Management Bureau (Project FC-F-6-2018). | |
| dc.description.abstract | This work describes an electrochemical sensor for the selective recognition and quantification of amoxicillin and a beta-lactam antibiotic in real samples. This sensor consists of a carbon paste electrode (CPE) modified with mag-MIP (magnetic molecularly imprinted polymer), which was prepared by precipitation method via free radical using acrylamide (AAm) as functional monomer, N,N '-methylenebisacrylamide (MBAA) as a crosslinker, and potassium persulfate (KPS) as initiator, to functionalized magnetic nanoparticles. The magnetic non-imprinted polymers (mag-NIP) were prepared using the same experimental procedure without analyte and used for the preparation of a CPE for comparative studies. The morphological, structural, and electrochemical characteristics of the nanostructured material were evaluated using Field emission gun scanning electron microscopy (FEG-SEM), Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), Vibrating sample magnetometry (VSM), X-ray diffraction (XRD), and voltammetric technique. Electrochemical experiments performed by square wave voltammetry show that the mag-MIP/CPE sensor had a better signal response compared to the non-imprinted polymer-modified electrode (mag-NIP/CPE). The sensor showed a linear range from 2.5 to 57 mu mol L-1 of amoxicillin (r(2) = 0.9964), with a limit of detection and a limit of quantification of 0.75 and 2.48 mu mol L-1, respectively. No significant interference in the electrochemical signal of amoxicillin was observed during the testing experiments in real samples (skimmed milk and river water). The proposed mag-MIP/CPE sensor could be used as a good alternative method to confront other techniques to determine amoxicillin in different samples. | |
| dc.description.sponsorship | Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec | |
| dc.identifier.doi | https://doi.org/10.3389/fchem.2021.615602 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12390/2927 | |
| dc.language.iso | eng | |
| dc.publisher | Frontiers Media SA | |
| dc.relation.ispartof | FRONTIERS IN CHEMISTRY | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | selective adsorption | |
| dc.subject | mag-MIP | es_PE |
| dc.subject | amoxicillin | es_PE |
| dc.subject | electrochemical sensor | es_PE |
| dc.subject | carbon paste electrode | es_PE |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#2.02.02 | |
| dc.title | Development of a New Electrochemical Sensor Based on Mag-MIP Selective Toward Amoxicillin in Different Samples | |
| dc.type | info:eu-repo/semantics/article | |
| dspace.entity.type | Publication |