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Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clones II and III in Lima, Peru article

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dc.contributor.author Levy-Blitchtein S. es_PE
dc.contributor.author Roca I. es_PE
dc.contributor.author Plasencia-Rebata S. es_PE
dc.contributor.author Vicente-Taboada W. es_PE
dc.contributor.author Velásquez-Pomar J. es_PE
dc.contributor.author Muñoz L. es_PE
dc.contributor.author Moreno-Morales J. es_PE
dc.contributor.author Pons M.J. es_PE
dc.contributor.author Del Valle-Mendoza J. es_PE
dc.contributor.author Vila J. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2018
dc.description.abstract Carbapenem-resistant Acinetobacter baumannii is the top-ranked pathogen in the World Health Organization priority list of antibiotic-resistant bacteria. It emerged as a global pathogen due to the successful expansion of a few epidemic lineages, or international clones (ICs), producing acquired class D carbapenemases (OXA-type). During the past decade, however, reports regarding IC-I isolates in Latin America are scarce and are non-existent for IC-II and IC-III isolates. This study evaluates the molecular mechanisms of carbapenem resistance and the epidemiology of 80 non-duplicate clinical samples of A. baumannii collected from February 2014 through April 2016 at two tertiary care hospitals in Lima. Almost all isolates were carbapenem-resistant (97.5%), and susceptibility only remained high for colistin (95%). Pulsed-field gel electrophoresis showed two main clusters spread between both hospitals: cluster D containing 51 isolates (63.8%) associated with sequence type 2 (ST2) and carrying OXA-72, and cluster F containing 13 isolates (16.3%) associated with ST79 and also carrying OXA-72. ST2 and ST79 were endemic in at least one of the hospitals. ST1 and ST3 OXA-23-producing isolates were also identified. They accounted for sporadic hospital isolates. Interestingly, two isolates carried the novel OXA-253 variant of OXA-143 together with an upstream novel insertion sequence (ISAba47). While the predominant A. baumannii lineages in Latin America are linked to ST79, ST25, ST15, and ST1 producing OXA-23 enzymes, we report the emergence of highly resistant ST2 (IC-II) isolates in Peru producing OXA-72 and the first identification of ST3 isolates (IC-III) in Latin America, both considered a serious threat to public health worldwide.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.1038/s41426-018-0127-9
dc.identifier.scopus 2-s2.0-85049520892
dc.identifier.uri https://hdl.handle.net/20.500.12390/590
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof Emerging Microbes and Infections
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject tertiary care center
dc.subject carbapenem es_PE
dc.subject carbapenem derivative es_PE
dc.subject Acinetobacter baumannii es_PE
dc.subject Article es_PE
dc.subject bacterium isolation es_PE
dc.subject carbapenem-resistant Enterobacteriaceae es_PE
dc.subject gene insertion sequence es_PE
dc.subject human es_PE
dc.subject nonhuman es_PE
dc.subject Peru es_PE
dc.subject priority journal es_PE
dc.subject pulsed field gel electrophoresis es_PE
dc.subject South and Central America es_PE
dc.subject Acinetobacter baumannii es_PE
dc.subject Acinetobacter infection es_PE
dc.subject bacterial gene es_PE
dc.subject beta-lactam resistance es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.011
dc.title Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clones II and III in Lima, Peru article
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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