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Preliminary safety evaluation of n-butanol from the collagen extraction process and of collagen extract from Oreochromis niloticus (tilapia) skin oriented for dermocosmetics

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dc.contributor.author Sánchez Tuesta, Linda Cristina es_PE
dc.contributor.author Reátegui Pinedo, Nataly Yahayra es_PE
dc.contributor.author Salirrosas Fernández, Remigio David es_PE
dc.contributor.author Morocho-Jácome, Ana Lucía es_PE
dc.contributor.author Daud Sarruf, Fernanda es_PE
dc.contributor.author Miliani Martinez, Renata es_PE
dc.contributor.author Quevedo-León, Roberto es_PE
dc.contributor.author Fiestas Jacinto, Ramiro es_PE
dc.contributor.author Ayala-Jara, Carmen es_PE
dc.contributor.author Rolim Baby, André es_PE
dc.contributor.author Prieto Lara, Zulita Adriana es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2021
dc.description Authors are very thankful to CONCYTECFONDECYT, process E041-01 (Contract number 123-2018-FONDECYT-BM-IADT/AV), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Process 305250/2019-1, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES) Finance Code 001 and Programa Nacional de Pós-Doutorado (PNPD).
dc.description.abstract Obtaining new cosmetic ingredients, mainly from sustainable sources, as novel excipients or even active compounds is noteworthy for the cosmetic industry to enhance new innovative dermocosmetics. Thus, it is essential to establish the safety of these new ingredients to avoid adverse events, mainly those associated with clastogenic effects from the chemical compounds used for collagen extraction. In this study, we evaluated solutions of chemical compounds used in the collagen extraction process from tilapia skin (Oreochromis niloticus). The cytotoxic and genotoxic effects of the solutions used in the collagen extraction process were 10.0, 1.0, 0.5, and 0.1% n-butanol. Solutions were evaluated by the Allium test and the comet assay in peripheral white blood cells. The residual water from the final skin wash in the pre-treatment phase and the 0.5% lyophilized collagen extract were also investigated. The absence of cytotoxic and genotoxic activity was demonstrated in the collagen extract, despite the fact that n-butanol showed DNA damage, both in the root cells of Allium cepa and in the white blood cells of human peripheral blood. Therefore, we note the necessity to carry out genotoxicity tests to guarantee the absence of contaminants in the collagen extract for cosmetic purposes.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.19277/bbr.18.1.256
dc.identifier.uri https://hdl.handle.net/20.500.12390/3163
dc.language.iso eng
dc.publisher Associação Lusófona para o Desenvolvimento da investigação e Ensino em Ciências da Saúde (ALIES)
dc.relation.ispartof Biomedical and Biopharmaceutical Research Journal
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Oreochromis niloticus
dc.subject Allium test es_PE
dc.subject collagen extraction es_PE
dc.subject Comet assay es_PE
dc.subject cytotoxicity es_PE
dc.subject genotoxicity es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.27
dc.title Preliminary safety evaluation of n-butanol from the collagen extraction process and of collagen extract from Oreochromis niloticus (tilapia) skin oriented for dermocosmetics
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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