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Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes

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dc.contributor.author Clark D. es_PE
dc.contributor.author Albrecht M. es_PE
dc.contributor.author Arévalo J. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 1994
dc.description This work was supported in part by a grant from the Consejo Nacional de Ciencia y Tecnologla (CONCYTEC). We thank W. Behrens and C. Santa Cruz for helpful advice on HPLC analysis and T. cruzi culture, and H. Guerra and C. Guerra for critically reading the manuscript.
dc.description.abstract Trypanosoma cruzi, the causative agent of Chagas' disease, has been considered for many years as an organism with limited capability to metabolize hydrogen peroxide (H202) [1]. This was supported by undetectable levels of peroxide-removing enzymes (catalase, glutathione peroxidase) and its high sensitivity to drugs like fl-lapachone and nifurtimox that generate superoxide anion (02-) and H202 through intracellular nitroreductases [2]. Paradoxically, T. cruzi parasites are naturally exposed to endogenous and exogenously generated reactive oxygen species through their life cycle. Microsomal and mitochondrial fractions, as well as fumarate reductase from T. cruzi can generate 02- and H202 [2,3]. Furthermore, the parasite can eventually be exposed to an oxidative stress when taken up by macrophages [4,5].
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.1016/0166-6851(94)90045-0
dc.identifier.scopus 2-s2.0-0028148024
dc.identifier.uri https://hdl.handle.net/20.500.12390/793
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Molecular and Biochemical Parasitology
dc.rights info:eu-repo/semantics/openAccess
dc.subject dehydroascorbic acid reductase
dc.subject ascorbic acid es_PE
dc.subject animal experiment es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.title Ascorbate variations and dehydroascorbate reductase activity in Trypanosoma cruzi epimastigotes and trypomastigotes
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
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