Publicación:
Association of salivary inflammatory biomarkers with primary Sjögren's syndrome
Association of salivary inflammatory biomarkers with primary Sjögren's syndrome
dc.contributor.author | Moreno-Quispe L.A. | es_PE |
dc.contributor.author | Serrano J. | es_PE |
dc.contributor.author | Virto L. | es_PE |
dc.contributor.author | Sanz M. | es_PE |
dc.contributor.author | Ramírez L. | es_PE |
dc.contributor.author | Fernández-Castro M. | es_PE |
dc.contributor.author | Hernández G. | es_PE |
dc.contributor.author | López-Pintor R.M. | es_PE |
dc.date.accessioned | 2024-05-30T23:13:38Z | |
dc.date.available | 2024-05-30T23:13:38Z | |
dc.date.issued | 2020 | |
dc.description.abstract | Background: Primary Sjogren's syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper-2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of interleukin (IL)-6, IL-5, and IL-4 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow, patient-reported outcomes (PROMs) for xerostomia and oral health quality of life (Oral Health Impact Profile-14 [OHIP-14]), pSS classification criteria and presence of extraglandular manifestations. Methods: A case-control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high-sensitivity multiplex map human immunoassays. Unstimulated and stimulated whole saliva were collected and patients filled out questionnaires. The Mann-Whitney U test, chi-squared test, and Spearman correlation test were used. Results: Interleukin-6 was significantly higher in pSS patients than in HCs (P =.0001). IL-6 was significantly higher in pSS patients with a positive salivary gland biopsy (P =.04), whole stimulated saliva hyposalivation (P =.02), and presence of musculoskeletal disorders (P =.03). There was a non-significant positive correlation between IL-6 levels and PROMs for xerostomia (r =.31; P =.06) and OHIP-14 (r =.07; P =.68) in pSS patients. Levels of IL-4 and IL-5 were not detected in both pSS and HCs patients. Conclusions: Salivary IL-6 levels are significantly associated with pSS patients, and therefore, it is hypothesized that this biomarker may be useful in the diagnosis and follow-up of this disease. © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd | |
dc.description.sponsorship | Fondo Nacional de Desarrollo Científico y Tecnológico - Fondecyt | |
dc.identifier.doi | https://doi.org/10.1111/jop.13070 | |
dc.identifier.scopus | 2-s2.0-85087318235 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12390/2478 | |
dc.language.iso | eng | |
dc.publisher | Blackwell Publishing Ltd | |
dc.relation.ispartof | Journal of Oral Pathology and Medicine | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Visual Analog Scale for xerostomia | |
dc.subject | Oral Health Impact Profile-14 | es_PE |
dc.subject | primary Sjögrens syndrome | es_PE |
dc.subject | Salivary biomarkers | es_PE |
dc.subject | salivary interleukins | es_PE |
dc.subject.ocde | http://purl.org/pe-repo/ocde/ford#3.03.08 | |
dc.title | Association of salivary inflammatory biomarkers with primary Sjögren's syndrome | |
dc.type | info:eu-repo/semantics/article | |
dspace.entity.type | Publication | |
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