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Liver clear cell foci and viral infection are associated with non-cirrhotic, non-fibrolamellar hepatocellular carcinoma in young patients from South America

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dc.contributor.author Cano, Luis es_PE
dc.contributor.author Cerapio, Juan Pablo es_PE
dc.contributor.author Ruiz, Eloy es_PE
dc.contributor.author Marchio, Agnes es_PE
dc.contributor.author Turlin, Bruno es_PE
dc.contributor.author Casavilca, Sandro es_PE
dc.contributor.author Taxa, Luis es_PE
dc.contributor.author Marti, Guillaume es_PE
dc.contributor.author Deharo, Eric es_PE
dc.contributor.author Pineau, Pascal es_PE
dc.contributor.author Bertani, Stéphane es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2018
dc.description.abstract We previously described a divergent clinical and molecular presentation of hepatocellular carcinoma (HCC) in Peru. The present study aimed to further characterize the tissue features associated with this singular nosological form of HCC in order to gain insight into the natural history of the disease. We performed an exploratory analysis of the histology of both tumor and non-tumor liver (NTL) tissues from 50 Peruvian HCC patients, and compared with that of 75 individuals with non-HCC liver tumor or benign liver lesions as a baseline for NTL features. We complemented this approach with a transcriptome analysis in a subset of NTL tissue samples and also performed an ultra-sensitive hepatitis B virus (HBV) detection in liver tissues of the patients. Overall, results highlighted the low rate of liver parenchymal alterations in a young patient cohort (median age: 40 years old), despite a strong prevalence of underlying HBV infection (c. 67%). Withal, liver clear cell foci of cellular alteration were genuinely associated with HCC and appended to some changes in immune and G protein-coupled receptor gene expression ontologies. Our findings confirm the occurrence of a particular setting of HCC in South America, a region where the pathophysiology of liver cancer remains largely unexplored. © 2018, The Author(s).
dc.description.sponsorship Fondo Nacional de Desarrollo Científico y Tecnológico - Fondecyt
dc.identifier.doi https://doi.org/10.1038/s41598-018-28286-0
dc.identifier.scopus 2-s2.0-85050796372
dc.identifier.uri https://hdl.handle.net/20.500.12390/2762
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof Scientific Reports
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject virus DNA
dc.subject alpha fetoprotein es_PE
dc.subject transcriptome es_PE
dc.subject.ocde http://purl.org/pe-repo/ocde/ford#3.04.03
dc.title Liver clear cell foci and viral infection are associated with non-cirrhotic, non-fibrolamellar hepatocellular carcinoma in young patients from South America
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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