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Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru

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dc.contributor.author Schiaffino, Francesca es_PE
dc.contributor.author Lee, Gwenyth O. es_PE
dc.contributor.author Paredes-Olortegui, Maribel es_PE
dc.contributor.author Cabrera, Lilia es_PE
dc.contributor.author Penataro-Yor, Pablo es_PE
dc.contributor.author Gilman, Robert H. es_PE
dc.contributor.author Kosek, Margaret N. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2019
dc.description This work was supported by the National Institutes of Health (NIH) 5D43TW009349–03 “Inter-American Training for Innovations in Emerging Infectious Diseases” (to GOL). F. S. was supported by FONDECYT-CONCYTEC (grant contract number 246–2015-FONDECYT), and the UJMT Fogarty Global Health Fellows Consortium comprising Johns Hopkins University, the University of North Carolina, Morehouse University, and Tulane University (NIH Research Training Grant # D43 TW009340 funded by the NIH Fogarty International Center, NINDS, NIMH, NHBLI and NIEHS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.description.abstract Background Bacillus Calmette-Guerin (BCG) scar formation is considered a visual marker of vaccination and cell-mediated immune response. This study characterized the association between pregnancy and birth characteristics with BCG scar formation. Study Design Pregnant women were enrolled prospectively. Infants were followed up for the first 6 months of life, and the diameter of the BCG scar was recorded. Marginal models were fitted to assess the association of BCG scar diameter with pregnancy and birth characteristics using linear regressions with generalized estimating equations. Results A total of 307 infants were enrolled, of whom 19.2% (59/307) were of low birth weight. Among those with known gestational age, 7.1% were preterm births (21/295). Overall, 98.7% (303/307) of infants developed a BCG scar. BCG scar trends in a tropical environment, such as the Amazon, differ from the trends evidenced in the capital of Peru. For every additional week of gestational age, the mean scar diameter increased by 0.1 mm (95% confidence interval [CI]: 0.02, 0.24; p = 0.017). Maternal illness during pregnancy impacted BCG scar size, as the infants of mothers who self-report fever had a smaller scar diameter (1 mm, 95% CI: 0.5, 1.8 mm; p = 0.001). Conclusion The immune reaction to the BCG vaccination is affected by gestational age at birth and systemic inflammatory episodes during pregnancy. © 2019 Georg Thieme Verlag KG Stuttgart New York.
dc.description.sponsorship Fondo Nacional de Desarrollo Científico y Tecnológico - Fondecyt
dc.identifier.doi https://doi.org/10.1055/s-0038-1676614
dc.identifier.scopus 2-s2.0-85072904453
dc.identifier.uri https://hdl.handle.net/20.500.12390/2749
dc.language.iso eng
dc.publisher Thieme Medical Publishers, Inc.
dc.relation.ispartof American Journal of Perinatology
dc.rights info:eu-repo/semantics/openAccess
dc.subject tuberculosis
dc.subject Bacillus Calmette-Guerin es_PE
dc.subject Peru es_PE
dc.subject preterm births es_PE
dc.subject.ocde http://purl.org/pe-repo/ocde/ford#3.01.03
dc.title Evolution of the Bacillus Calmette-Guerin Scar and Its Association with Birth and Pregnancy Characteristics in a Prospective Cohort of Infants in Iquitos, Peru
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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