Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol Rubio J. es_PE Yucra S. es_PE Gasco M. es_PE Gonzales G.F. es_PE 2024-05-30T23:13:38Z 2024-05-30T23:13:38Z 2011
dc.description The present study was supported by a grant obtained from Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2008. All authors participated in the experimental design and development of the study. Also, the authors report no conflicts of interest. The study was performed in 2008. Since 2009, Dr Gustavo F. Gonzales is in charged of CAYENATUR EIRL an enterprise that develops products based on Maca.
dc.description.abstract Previous studies have shown that black variety of maca has beneficial effects on learning and memory in experimental animal models. The present study aimed to determine whether the hydroalcoholic extract of black maca (BM) showed a dose–response effect in mice treated with ethanol 20% (EtOH) as a model of memory impairment. Mice were divided in the following groups: control, EtOH, ascorbic acid (AA) and 0.125, 0.25, 0.50 and 1.00 g/kg of BM plus EtOH. All treatments were orally administered for 28 days. Open field test was performed to determine locomotor activity and water Morris maze was done to determine spatial memory. Also, total polyphenol content in the hydroalcoholic extract of BM was determined (0.65 g pyrogallol/100 g). Mice treated with EtOH took more time to find the hidden platform than control during escape acquisition trials; meanwhile, AA and BM reversed the effect of EtOH. In addition, AA and BM ameliorated the deleterious effect of EtOH during the probe trial. Correlation analyses showed that the effect of BM a dose-dependent behavior. Finally, BM improved experimental memory impairment induced by ethanol in a dose–response manner due, in part, to its content of polyphenolic compounds.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.scopus 2-s2.0-80053264500
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Toxicology Mechanisms and Methods
dc.rights info:eu-repo/semantics/openAccess
dc.subject pyrogallol
dc.subject ascorbic acid es_PE
dc.subject Lepidium meyenii extract es_PE
dc.subject polyphenol es_PE
dc.subject alcohol es_PE
dc.subject plant extract es_PE
dc.subject animal experiment es_PE
dc.subject controlled study es_PE
dc.subject dose response es_PE
dc.subject drug effect es_PE
dc.subject locomotion es_PE
dc.subject male es_PE
dc.subject memory disorder es_PE
dc.title Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
dc.type info:eu-repo/semantics/review
dspace.entity.type Publication