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Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
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Fecha
2011
Autores
Rubio J.
Yucra S.
Gasco M.
Gonzales G.F.
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Elsevier
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Abstracto
Previous studies have shown that black variety of maca has beneficial effects on learning and memory in experimental animal models. The present study aimed to determine whether the hydroalcoholic extract of black maca (BM) showed a dose–response effect in mice treated with ethanol 20% (EtOH) as a model of memory impairment. Mice were divided in the following groups: control, EtOH, ascorbic acid (AA) and 0.125, 0.25, 0.50 and 1.00 g/kg of BM plus EtOH. All treatments were orally administered for 28 days. Open field test was performed to determine locomotor activity and water Morris maze was done to determine spatial memory. Also, total polyphenol content in the hydroalcoholic extract of BM was determined (0.65 g pyrogallol/100 g). Mice treated with EtOH took more time to find the hidden platform than control during escape acquisition trials; meanwhile, AA and BM reversed the effect of EtOH. In addition, AA and BM ameliorated the deleterious effect of EtOH during the probe trial. Correlation analyses showed that the effect of BM a dose-dependent behavior. Finally, BM improved experimental memory impairment induced by ethanol in a dose–response manner due, in part, to its content of polyphenolic compounds.
Descripción
The present study was supported by a grant obtained from Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2008. All authors participated in the experimental design and development of the study. Also, the authors report no conflicts of interest. The study was performed in 2008. Since 2009, Dr Gustavo F. Gonzales is in charged of CAYENATUR EIRL an enterprise that develops products based on Maca.
Palabras clave
pyrogallol,
ascorbic acid,
Lepidium meyenii extract,
polyphenol,
alcohol,
plant extract,
animal experiment,
controlled study,
dose response,
drug effect,
locomotion,
male,
memory disorder