Publicación:
IFN-gamma production in response to Tax 161-233, and frequency of CD4(+) Foxp3(+) and Lin(-) HLA-DRhigh CD123(+) cells, discriminate HAM/TSP patients from asymptomatic HTLV-1-carriers in a Peruvian population
IFN-gamma production in response to Tax 161-233, and frequency of CD4(+) Foxp3(+) and Lin(-) HLA-DRhigh CD123(+) cells, discriminate HAM/TSP patients from asymptomatic HTLV-1-carriers in a Peruvian population
| dc.contributor.author | Best, I | es_PE |
| dc.contributor.author | Lopez, G | es_PE |
| dc.contributor.author | Verdonck, K | es_PE |
| dc.contributor.author | Gonzalez, E | es_PE |
| dc.contributor.author | Tipismana, M | es_PE |
| dc.contributor.author | Gotuzzo, E | es_PE |
| dc.contributor.author | Vanham, G | es_PE |
| dc.contributor.author | Clark, D | es_PE |
| dc.date.accessioned | 2024-05-30T23:13:38Z | |
| dc.date.available | 2024-05-30T23:13:38Z | |
| dc.date.issued | 2009 | |
| dc.description.abstract | Human T-lymphotropic virus 1 (HTLV-1) can cause HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The objective of this study was to gain insight into the pathogenesis of HAM/TSP by focusing on the CD8(+) T-cell response. Twenty-three HTLV-1-seronegative controls (SC), 29 asymptomatic HTLV-1 carriers (AC) and 48 patients with HAM/TSP were enrolled in the study. We evaluated the production of interferon-gamma (IFN-gamma) in peripheral blood mononuclear cells stimulated with Tax overlapping peptides, the expression of genes related to the CD8(+) cytotoxic T-cell response, the frequency of CD4(+) Foxp3(+) cells and of dendritic cells, and the HTLV-1 provirus load (PVL). The frequency of cells producing IFN-gamma in response to Tax 161-233, but not to Tax 11-19, discriminated patients with HAM/TSP from AC. The increased pro-inflammatory response observed in patients with HAM/TSP was shared by AC with a high PVL, who also exhibited lower levels of granzyme H mRNA in unstimulated CD8(+) T cells than AC with a low PVL. Patients with HAM/TSP showed higher frequencies of CD4(+) Foxp3(+) cells and lower frequencies of plasmacytoid dendritic cells (pDC) than AC. Our findings are consistent with a model in which HTLV-1, along with the host genetic background, drives quantitative and qualitative changes in pDC and CD4(+) Foxp3(+) cells that lead to a predominance of inflammatory responses over lytic responses in the CD8(+) T-cell response of individuals predisposed to develop HAM/TSP. | en |
| dc.description.sponsorship | Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec | |
| dc.identifier.doi | https://doi.org/10.1111/j.1365-2567.2009.03082.x | |
| dc.identifier.isi | 268703800063 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12390/1157 | |
| dc.language.iso | eng | |
| dc.publisher | Wiley-Blackwell Publishing Ltd | en |
| dc.relation.ispartof | Immunology | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | CD8+ T-cell response | eng |
| dc.subject | Human T-lymphotropic virus 1 | eng |
| dc.subject | Paraparesis | eng |
| dc.title | IFN-gamma production in response to Tax 161-233, and frequency of CD4(+) Foxp3(+) and Lin(-) HLA-DRhigh CD123(+) cells, discriminate HAM/TSP patients from asymptomatic HTLV-1-carriers in a Peruvian population | |
| dc.type | info:eu-repo/semantics/article | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# |