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PublicaciónA contemporary approach to the MSE paradigm powered by Artificial Intelligence from a review focused on Polymer Matrix Composites(Taylor & Francis INC, 2021)
;Gomez, C. ;Guardia, A. ;Mantari, J. L. ;Coronado, A. M.Reddy, J. N.Artificial Intelligence (AI) is a broad discipline that uses powerful algorithms to emulate important aspects of human intelligence. Provided by the Industry 4.0 revolution, AI is increasingly applied in different fields from research to production. One of these fields is Materials Science and Engineering (MSE) which studies the relationships between processing, structure, properties, and performance of materials. The application of AI to MSE has triggered the invention of new materials to satisfy the demanding requirements in myriad sectors through the years. In this context, the MSE paradigm emerged as a framework to define these relationships supported by the available technologies at the corresponding time. This is how Polymer Matrix Composites (PMC) were synthesized. During the last years, they have turned from a futuristic solution to a necessity due to the wide range of advantages they offer concerning other conventional materials. The present work presents a modified approach to the MSE paradigm with the application of AI algorithms. An overview of the research advances from 2003 to 2019 in each fundamental link of the proposed MSE paradigm for PMC is exhibited in an organized fashion. This article must serve engineers and scientists working at the intersection of mechanical engineering, materials science and computer science to identify trendy topics in these fields. It aims to represent a starting point for developing innovative methods and proposing new research topics in the framework of the MSE paradigm powered by AI for PMC. -
PublicaciónA greenhouse interval between icehouse times: Climate change, long-distance plant dispersal, and plate motion in the Mississippian (late Visean-earliest Serpukhovian) of Gondwana(Elsevier, 2014)
;Pfefferkorn H.W. ;Alleman V.Iannuzzi R.The late Paleozoic ice age (LPIA) is the closest example that can be compared with current climate conditions. Near the beginning of the LPIA fossil plants of Mississippian (late Visean to earliest Serpukhovian) age indicate a widespread frost-free climate in a wide belt on Gondwana indicating an interval of greenhouse conditions between the earlier Visean and later Serpukhovian icehouse times. This warm-temperate floral belt has been named the Paraca floral belt after the locality on the Peruvian coast where it was first recognized. -
PublicaciónA review on the negative impact of different elements during cyanidation of gold and silver from refractory ores and strategies to optimize the leaching process(Elsevier Ltd, 2021)
;Larrabure, G.Rodríguez-Reyes, J.C.F.The ongoing depletion of gold and silver-containing ore deposits demands a shift towards the processing of more complex sources. Leaching of gold or silver from these sources, which are named refractory and are typically low-grade, can be complicated due to one or more of the following effects: (1) kinetic or thermodynamic impediments on cyanide diffusion or on the dissolution of minerals, (2) readsorption of leached gold or silver (preg-robbing), and (3) excessive cyanide consumption due to the presence of cyanicidal agents. This article reviews the occurrence of these effects as a function of the elemental composition and compiles strategies to overcome them. The first type of refractory behavior was found to be related to arsenic or antimony sulfides and sulfosalts, manganese oxides, permanganates, iron sulfides, oxides, and hydroxides, tellurides, as well as different sulfur-containing minerals. In general, most kinetic or thermodynamic impediments are addressed by performing intensive grinding and through oxidation processes for sulfides, such as roasting, pressure oxidation, chemical oxidation or biological oxidation. On the other hand, preg-robbing activity was described as common in ores that contain carbonaceous matter, silicates, and sulfides. Strategies to deal with preg-robbing ores often include the destruction or deactivation of the preg-robbing surface, or the addition of another adsorbent to compete with the preg-robber (carbon-in-leach). Finally, cyanicidal agents include sulfides and compounds containing base metals, mainly copper, iron, zinc, and nickel. In the case of sulfides, performing oxidation processes is common, while base metals often require one or more pre-leaching stages in which they can be partially removed from the ore prior to cyanidation. Even though this review intends to serve as a compendium of strategies directed at improving cyanidation processes depending on the nature of the elements present in a feed, a final discussion stressing the importance of developing ore-specific strategies is given. © 2021 Elsevier Ltd -
PublicaciónAddressing post-stroke care in rural areas with Peru as a case study. Placing emphasis on evidence-based pragmatism(Elsevier, 2017)
;Miranda J.J. ;Moscoso M.G. ;Yan L.L. ;Diez-Canseco F. ;Málaga G. ;Garcia H.H.Ovbiagele B.Stroke is a major cause of death and disability, with most of its burden now affecting low- and middle-income countries (LMIC). People in rural areas of LMIC who have a stroke receive very little acute stroke care and local healthcare workers and family caregivers in these regions lack the necessary knowledge to assist them. Intriguingly, a recent rapid growth in cell-phone use and digital technology in rural areas has not yet been appropriately exploited for health care training and delivery purposes. What should be done in rural areas, at the community setting-level, where access to healthcare is limited remains a challenge. We review the evidence on improving post-stroke outcomes including lowering the risks of functional disability, stroke recurrence, and mortality, and propose some approaches, to target post-stroke care and rehabilitation, noting key challenges in designing suitable interventions and emphasizing the advantages mHealth and communication technologies can offer. -
PublicaciónAdvances in the design and application of transition metal oxide-based supercapacitors(De Gruyter Poland Sp. z o.o., 2021)
;Quispe-Garrido, Vanessa ;Cerron-Calle, Gabriel Antonio ;Bazan-Aguilar, Antony ;Ruiz-Montoya, Jose G. ;Lopez, Elvis O.Baena-Moncada, Angelica M.In the last years, supercapacitors (SCs) have been proposed as a promising alternative to cover the power density deficiency presented in batteries. Electrical double-layer SCs, pseudocapacitors, and hybrid supercapacitors (HSCs) have shown very attractive features such as high-power density, long cycle life, and tunable specific capacitance. The advances of these energy storage devices made by transition metal oxides (TMOs) and their production in pseudocapacitors and HSCs depend on chemical composition, crystalline structure, morphology, theoretical capacitance, and oxidation states. In this way, this critical review considers several metal oxides (RuO2, MnO2, V2O5, and Co3O4) and their different configurations with diverse carbon-based materials. Energy storage mechanisms and fundamental principles to understand the promising effect of metal oxides in SCs devices are thoroughly described. Special attention as regards to the energy storage mechanisms relative to the specific capacitance values is presented in the reviewed articles. This review envisages the TMO as a key component to obtain high specific capacitance SCs. -
PublicaciónCombining ultrasound, vacuum and/or ethanol as pretreatments to the convective drying of celery slices(Elsevier B.V., 2021)
;Miano A.C. ;Rojas M.L.Augusto P.E.D.This work studied three emerging approaches to improve the convective drying (50 °C, 0.8 m/s) of celery. Celery slices of 2 mm thick were pretreated for 5 min using ultrasound (32 W/L, 40 kHz), vacuum (75 kPa vacuum pressure) and ethanol (99.8% v/v, as drying accelerator) applied individually or in combination. To evaluate individual effects of ultrasound and vacuum, the treatments were also performed with distilled water or air medium, respectively. Moreover, the cavitational level was characterized in each condition. Drying kinetics was evaluated tending into account the drying time required by each treatment and the Page's model parameters. In addition, microstructural effects and shrinkage were evaluated. As results, ethanol combined with ultrasound significantly improved drying kinetics reducing drying time by around 38%. However, vacuum pretreatment did not affect drying kinetics even in combination with ethanol and/or ultrasound. Microstructural evaluation did not evidence cell disruption, suggesting changes in intercellular spaces, pores and/or cell wall permeability. The use of ethanol and vacuum showed a greater effect on shrinkage after pretreatment and after drying, respectively. In conclusion, at the studied conditions, the drying acceleration by vacuum and ultrasound is lower compared to the effect produced using ethanol. © 2021 The Authors -
PublicaciónCurrent practices in missing data handling for interrupted time series studies performed on individual-level data: A scoping review in health research(Dove Medical Press Ltd, 2021)
;Bazo-Alvarez J.C. ;Morris T.P. ;Carpenter J.R.Petersen I.Objective: Missing data can produce biased estimates in interrupted time series (ITS) analyses. We reviewed recent ITS investigations on health topics for determining 1) the data management strategies and statistical analysis performed, 2) how often missing data were considered and, if so, how they were evaluated, reported and handled. Study Design and Setting: This was a scoping review following standard recommendations from the PRISMA Extension for Scoping Reviews. We included a random sample of all ITS studies that assessed any intervention relevant to health care (eg, policies or programmes) with individual-level data, published in 2019, with abstracts indexed on MEDLINE. Results: From 732 studies identified, we finally reviewed 60. Reporting of missing data was rare. Data aggregation, statistical tools for modelling population-level data and complete case analyses were preferred, but these can lead to bias when data are missing at random. Seasonality and other time-dependent confounders were rarely accounted for and, when they were, missing data implications were typically ignored. Very few studies reflected on the consequences of missing data. Conclusion: Handling and reporting of missing data in recent ITS studies performed for health research have many shortcomings compared with best practice. © 2021 Bazo-Alvarez et al. -
PublicaciónDiagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy(IOS PRESS, 2021)
;Chavez-Fumagalli, Miguel A. ;Shrivastava, Pallavi ;Aguilar-Pineda, Jorge A. ;Nieto-Montesinos, Rita ;Davila Del-Carpio, Gonzalo ;Peralta-Mestas, Antero ;Caracela-Zeballos, Claudia ;Valdez-Lazo, Guillermo ;Fernandez-Macedo, Victor ;Pino-Figueroa, Alejandro ;Vera-Lopez, Karin J.Lino Cardenas, Christian L.Background: The present systematic review and meta-analysis of diagnostic test accuracy summarizes the last three decades in advances on diagnosis of Alzheimer's disease (AD) in developed and developing countries. Objective: To determine the accuracy of biomarkers in diagnostic tools in AD, for example, cerebrospinal fluid, positron emission tomography (PET), and magnetic resonance imaging (MRI), etc. Methods: The authors searched PubMed for published studies from 1990 to April 2020 on AD diagnostic biomarkers. 84 published studies were pooled and analyzed in this meta-analysis and diagnostic accuracywas compared by summary receiver operating characteristic statistics. Results: Overall, 84 studies met the criteria and were included in a meta-analysis. For EEG, the sensitivity ranged from 67 to 98%, with a median of 80%, 95%CI [75, 91], tau-PET diagnosis sensitivity ranged from 76 to 97%, with a median of 94%, 95%CI [76, 97]; and MRI sensitivity ranged from 41 to 99%, with a median of 84%, 95%CI [81, 87]. Our results showed that tau-PET diagnosis had higher performance as compared to other diagnostic methods in this meta-analysis. Conclusion: Our findings showed an important discrepancy in diagnostic data for AD between developed and developing countries, which can impact global prevalence estimation and management of AD. Also, our analysis found a better performance for the tau-PET diagnostic over other methods to diagnose AD patients, but the expense of tau-PET scan seems to be the limiting factor in the diagnosis of AD in developing countries such as those found in Asia, Africa, and Latin America. -
PublicaciónDifferentiating nanomaghemite and nanomagnetite and discussing their importance in arsenic and lead removal from contaminated effluents: A critical review(MDPI, 2021)
;Ramos-Guivar J.A. ;Flores-Cano D.A.Passamani E.C.Arsenic and lead heavy metals are polluting agents still present in water bodies, including surface (lake, river) and underground waters; consequently, the development of new adsorbents is necessary to uptake these metals with high efficiency, quick and clean removal procedures. Magnetic nanoparticles, prepared with iron-oxides, are excellent candidates to achieve this goal due to their ecofriendly features, high catalytic response, specific surface area, and pulling magnetic response that favors an easy removal. In particular, nanomagnetite and maghemite are often found as the core and primary materials regarding magnetic nanoadsorbents. However, these phases show interesting distinct physical properties (especially in their surface magnetic properties) but are not often studied regarding correlations between the surface properties and adsorption applications, for instance. Thus, in this review, we summarize the main characteristics of the co-precipitation and thermal decomposition methods used to prepare the nano-iron-oxides, being the co-precipitation method most promising for scaling up processes. We specifically highlight the main differences between both nano-oxide species based on conventional techniques, such as X-ray diffraction, zero and in-field Mössbauer spectroscopy, X-ray photoelectron spectroscopy, X-ray absorption spectroscopy, and X-ray magnetic circular dichroism, the latter two techniques performed with synchrotron light. Therefore, we classify the most recent magnetic nanoadsorbents found in the literature for arsenic and lead removal, discussing in detail their advantages and limitations based on various physicochemical parameters, such as temperature, competitive and coexisting ion effects, i.e., considering the simultaneous adsorption removal (heavy metal–heavy metal competition and heavy metal–organic removal), initial concentration, magnetic adsorbent dose, adsorption mechanism based on pH and zeta potential, and real water adsorption experiments. We also discuss the regeneration/recycling properties, after-adsorption physicochemical properties, and the cost evaluation of these magnetic nanoadsorbents, which are important issues, but less discussed in the literature. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. -
PublicaciónDoseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol(Elsevier, 2011)
;Rubio J. ;Yucra S. ;Gasco M.Gonzales G.F.Previous studies have shown that black variety of maca has beneficial effects on learning and memory in experimental animal models. The present study aimed to determine whether the hydroalcoholic extract of black maca (BM) showed a dose–response effect in mice treated with ethanol 20% (EtOH) as a model of memory impairment. Mice were divided in the following groups: control, EtOH, ascorbic acid (AA) and 0.125, 0.25, 0.50 and 1.00 g/kg of BM plus EtOH. All treatments were orally administered for 28 days. Open field test was performed to determine locomotor activity and water Morris maze was done to determine spatial memory. Also, total polyphenol content in the hydroalcoholic extract of BM was determined (0.65 g pyrogallol/100 g). Mice treated with EtOH took more time to find the hidden platform than control during escape acquisition trials; meanwhile, AA and BM reversed the effect of EtOH. In addition, AA and BM ameliorated the deleterious effect of EtOH during the probe trial. Correlation analyses showed that the effect of BM a dose-dependent behavior. Finally, BM improved experimental memory impairment induced by ethanol in a dose–response manner due, in part, to its content of polyphenolic compounds. -
PublicaciónEmerging contaminants, SARS-COV-2 and wastewater treatment plants, new challenges to confront: A short review(Elsevier Ltd, 2021)
;Revilla Pacheco C. ;Terán Hilares R. ;Colina Andrade G. ;Mogrovejo-Valdivia A.Pacheco Tanaka D.A.The current pandemic caused by SARS-CoV-2 has put public health at risk, being wastewater-based epidemiology (WBE) a potential tool in the detection, prevention, and treatment of present and possible future outbreaks, since this virus enters wastewater through various sources such as feces, vomit, and sputum. Thus, advanced technologies such as advanced oxidation processes (AOP), membrane technology (MT) are identified through a systematic literature review as an alternative option for the destruction and removal of emerging contaminants (drugs and personal care products) released mainly by infected patients. The objectives of this review are to know the implications that the new COVID-19 outbreak is generating and will generate in water compartments, as well as the new challenges faced by wastewater treatment plants due to the change in a load of contaminants and the solutions proposed based on the aforementioned technologies to be applied to preserve public health and the environment. © 2021 Elsevier Ltd -
PublicaciónFamily aggregation of human T-lymphotropic virus 1-associated diseases: A systematic review(Frontiers Media S.A., 2016)
;Alvarez C. ;Gotuzzo E. ;Vandamme A.-M.Verdonck K.Human T-lymphotropic virus 1 (HTLV-1) is a retrovirus that produces a persistent infection. Two transmission routes (from mother to child and via sexual intercourse) favor familial clustering of HTLV-1. It is yet unknown why most HTLV-1 carriers remain asymptomatic while about 10% of them develop complications. HTLV-1 associated diseases were originally described as sporadic entities, but familial presentations have been reported. To explore what is known about family aggregation of HTLV-1-associated diseases we undertook a systematic review. We aimed at answering whether, when, and where family aggregation of HTLV-1-associated diseases was reported, which relatives were affected and which hypotheses were proposed to explain aggregation. We searched MEDLINE, abstract books of HTLV conferences and reference lists of selected papers. Search terms used referred to HTLV-1 infection, and HTLV-1-associated diseases, and family studies. HTLV-1-associated diseases considered are adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), HTLV-1-associated uveitis, and infective dermatitis. Seventy-four records reported HTLV-1-associated diseases in more than one member of the same family and were included. Most reports came from HTLV-1-endemic countries, mainly Japan (n = 30) and Brazil (n = 10). These reports described a total of 270 families in which more than one relative had HTLV-1-associated diseases. In most families, different family members suffered from the same disease (n = 223). The diseases most frequently reported were ATLL (115 families) and HAM/TSP (102 families). Most families (n = 144) included two to four affected individuals. The proportion of ATLL patients with family history of ATLL ranged from 2 to 26%. The proportion of HAM/TSP patients with family history of HAM/TSP ranged from 1 to 48%. The predominant cluster types for ATLL were clusters of siblings and parent-child pairs and for HAM/TSP, an affected parent with one or more affected children. The evidence in the literature, although weak, does suggest that HTLV-1-associated diseases sometimes cluster in families. Whether familial transmission of HTLV-1 is the only determining factor, or whether other factors are also involved, needs further research. -
PublicaciónFreshwater ecosystem services in mining regions: Modelling options for policy development support(MDPI AG, 2018)
;Mercado-Garcia D. ;Wyseure G.Goethals P.The ecosystem services (ES) approach offers an integrated perspective of social-ecological systems, suitable for holistic assessments of mining impacts. Yet for ES models to be policy-relevant, methodological consensus in mining contexts is needed. We review articles assessing ES in mining areas focusing on freshwater components and policy support potential. Twenty-six articles were analysed concerning (i) methodological complexity (data types, number of parameters, processes and ecosystem–human integration level) and (ii) potential applicability for policy development (communication of uncertainties, scenario simulation, stakeholder participation and management recommendations). Articles illustrate mining impacts on ES through valuation exercises mostly. However, the lack of ground- and surface-water measurements, as well as insufficient representation of the connectivity among soil, water and humans, leave room for improvements. Inclusion of mining-specific environmental stressors models, increasing resolution of topographies, determination of baseline ES patterns and inclusion of multi-stakeholder perspectives are advantageous for policy support. We argue that achieving more holistic assessments exhorts practitioners to aim for high social-ecological connectivity using mechanistic models where possible and using inductive methods only where necessary. Due to data constraints, cause–effect networks might be the most feasible and best solution. Thus, a policy-oriented framework is proposed, in which data science is directed to environmental modelling for analysis of mining impacts on water ES. -
PublicaciónGlobal Shifts in Cardiovascular Disease, the Epidemiologic Transition, and Other Contributing Factors: Toward a New Practice of Global Health Cardiology(W.B. Saunders, 2017)
;Mendoza W.Miranda J.J.The epidemiologic transition theory, since it was first proposed, gave an intellectual boost to understanding the changing dynamics of epidemiologic profiles. The epidemiologic transition provided a complement to the discourse of demographic change. Despite its criticisms and revisions, it is still a useful concept that influences public health debates, and has proved to be influential, particularly in changing societies. Most countries are facing the rapidly emerging needs of populations -
PublicaciónHorizontal gene transfer contributes to plant evolution: The case of agrobacterium T-DNAs(Frontiers Media S.A., 2017)
;Quispe-Huamanquispe D.G. ;Gheysen G.Kreuze J.F.Horizontal gene transfer (HGT) can be defined as the acquisition of genetic material from another organism without being its offspring. HGT is common in the microbial world including archaea and bacteria, where HGT mechanisms are widely understood and recognized as an important force in evolution. In eukaryotes, HGT now appears to occur more frequently than originally thought. Many studies are currently detecting novel HGT events among distinct lineages using next-generation sequencing. Most examples to date include gene transfers from bacterial donors to recipient organisms including fungi, plants, and animals. In plants, one well-studied example of HGT is the transfer of the tumor-inducing genes (T-DNAs) from some Agrobacterium species into their host plant genomes. Evidence of T-DNAs from Agrobacterium spp. into plant genomes, and their subsequent maintenance in the germline, has been reported in Nicotiana, Linaria and, more recently, in Ipomoea species. The transferred genes do not produce the usual disease phenotype, and appear to have a role in evolution of these plants. In this paper, we review previous reported cases of HGT from Agrobacterium, including the transfer of T-DNA regions from Agrobacterium spp. to the sweetpotato [Ipomoea batatas (L.) Lam.] genome which is, to date, the sole documented example of a naturally-occurring incidence of HGT from Agrobacterium to a domesticated crop plant. We also discuss the possible evolutionary impact of T-DNA acquisition on plants. -
PublicaciónMetabolismo mineral óseo en pacientes con enfermedad renal crónica: revisión sobre su fisiopatología y morbimortalidad(Instituto Nacional de Salud, 2015)
;Bernuy, JeanetteGonzales, Gustavo F.La enfermedad mineral ósea (EMO) es un término amplio que incluye a las alteraciones séricas del calcio, fósforo, vitamina D, paratohormona, anormalidades en el crecimiento, mineralización ósea y/o a las calcificaciones extraesqueléticas que acompañan al paciente con enfermedad renal crónica (ERC). Está presente en casi la totalidad de pacientes en diálisis y con el trasplante renal puede no siempre mejorar. Se han identificado nuevos factores y hormonas; como klotho y factor de crecimiento de fibroblastos-23 (FGF-23) que interactúan con la vitamina D y con la paratohormona en el manejo renal del calcio y fósforo. Ciertos reportes indican que son marcadores precoces del desarrollo de EMO, incluso cuando la función renal está levemente disminuida y los niveles de paratohormona son normales. La EMO ha sido asociada con mayor mortalidad, principalmente por su vinculación con la calcificación vascular. Este proceso conlleva a un incremento de eventos cardiovasculares que constituyen la principal causa de morbimortalidad en pacientes con ERC, sobre todo aquellos que se encuentran en diálisis, independientemente de la modalidad que los pacientes sigan. La forma de presentación de la EMO puede ser de alto o bajo recambio. Aunque no está completamente definido qué es lo que determina que se exprese una en particular, se ha encontrado que la enfermedad de bajo recambio se relaciona con malnutrición, uso inadecuado de calcitriol y diálisis ineficiente. El conocimiento de la EMO es relevante por su asociación con las complicaciones mencionadas y porque constituye un parámetro para evaluar la terapia instalada. -
PublicaciónModification of NaCl structure as a sodium reduction strategy in meat products: An overview(Elsevier Ltd, 2021)
;Rios-Mera, Juan D. ;Selani, Miriam M. ;Patinho, Iliana ;Saldaña, ErickContreras-Castillo, Carmen J.Sodium chloride (NaCl) is an indispensable ingredient in meat products, but the consumption of high doses of sodium contained in their formulations may bring about negative health implications. The replacement of NaCl by other salts in meat products has been a technological challenge. Accordingly, this review highlights the importance of NaCl over other sodium and non‑sodium salts in the saltiness perception and proposes the use of reduced-size and shapes of NaCl to maximize saltiness perception, while using less NaCl dosages in meat products. However, the effect of matrix components (water, proteins and fats) on the final salty taste is of special consideration. To counteract the effect of the matrix components, two main routes of incorporation of different NaCl types in meat products are discussed: encapsulation and protection of NaCl by the hydrophobic component of the meat product. Given the limited number of publications using this potential strategy, more studies on the application of these technological strategies are required. © 2020 Elsevier Ltd -
PublicaciónOutcomes following severe hand foot and mouth disease: A systematic review and meta-analysis(W.B. Saunders Ltd, 2018)
;Jones E. ;Pillay T.D. ;Liu F. ;Luo L. ;Bazo-Alvarez J.C. ;Yuan C. ;Zhao S. ;Chen Q. ;Li Y. ;Liao Q. ;Yu H. ;Rogier van Doorn H.Sabanathan S.Background. Hand, foot and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) is associated with acute neurological disease in children. This study aimed to estimate the burden of long-term sequelae and death following severe HFMD. Methods. This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015. Methods.This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015.Two independent reviewers assessed the literature.We used a random effects meta-analysis to estimate cumulative incidence of neurological sequelae or death. Studies were assessed for methodological and reporting quality. Findings. 43 studies were included in the review, and 599 children from 9 studies were included in the primary analysis. Estimated cumulative incidence of death or neurological sequelae at maximum follow up was 19.8% (95% CI:10.2%, 31.3%). Heterogeneity (Iˆ2) was 88.57%, partly accounted for by year of data collection and reporting quality of studies. Incidence by acute disease severity was 0.00% (0.00, 0.00) for grade IIa; 17.0% (7.9, 28.2) for grade IIb/III; 81.6% (65.1, 94.5) for grade IV (p = 0.00) disease. -
PublicaciónPeru's road to climate action: Are we on the right path? The role of life cycle methods to improve Peruvian national contributions(Elsevier, 2019)
;Vázquez-Rowe I. ;Kahhat R. ;Larrea-Gallegos G.Ziegler-Rodriguez K.Most developing nations have had to perform a swift transition from the voluntary greenhouse gas (GHG) emissions mitigation actions engaged in the Copenhagen Accord, to the relatively ambitious mitigations signed in the frame of the Paris Agreement. Consequently, Peru is currently creating its national structure to combat climate change through mitigation and adaptation actions. Nationally-determined contributions (NDCs) are the planned interventions that nations report for intended reductions in GHG emissions. -
PublicaciónPromising physicochemical technologies for poultry slaughterhouse wastewater treatment: A critical review(Elsevier Ltd, 2021)
;Hilares R.T. ;Atoche-Garay D.F. ;Pagaza D.A.P. ;Ahmed M.A. ;Andrade G.J.C.Santos J.C.Poultry slaughterhouse wastewater (PSWW) is a serious concern mainly due to the huge generation and associated characteristics of high organic matter and nutrients (N, P) that this contains. Therefore, an understanding development and adaption of an apposite wastewater treatment option focused specifically on PSWW is an absolute need. Recently, innovative physicochemical-based technologies, such as; acid precipitation, electrochemical advanced oxidation, cavitation-based processes and even nanotechnology assisted processes have been reported as prominent alternatives for wastewater treatment. In this article, we performed a systematic literature review and a comprehensive discussion about these technologies, aiming to show them as alternatives for PSWW treatment. Among all discussed technologies, hydrodynamic cavitation (HC) was observed as an interesting possibility that can be implemented in combination with other processes for efficient pollutant degradation. It could be, e.g., associated with nanoparticles, nanocomposites and nanobubbles, which are also an interesting alternative to be associated with membranes, generating turbulence, and mitigating problems as fouling. Finally, the wide knowledge about such treatment technologies can offer a more cost-effective PSWW management, thus, allowing an adequate implementation from technical and economical viewpoints. © 2021 Elsevier Ltd.