6.1 Proyectos de investigación científica

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https://hdl.handle.net/20.500.12390/383

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Examinando 6.1 Proyectos de investigación científica por Autor "rp00125"
  • Publicación
    Correcting the cut-off point of hemoglobin at high altitude favors misclassification of anemia, erythrocytosis and excessive erythrocytosis
    (Universidad Peruana Cayetano Heredia, 2018)
    Gonzales, GF
    ;
    de Celis, VR
    ;
    Begazo, J
    ;
    Hinojosa, MD
    ;
    Yucra, S
    ;
    Zevallos-Concha, A
    ;
    Tapia, V
    The World Health Organization (WHO) defines anemia according age, gender, and altitude based on statistical distribution considerations and by cut‐off points. Anemia in pregnancy and in children aged 6–59 months is defined as hemoglobin (Hb) concentration <11 g/dL. Since Hb contains almost 70% of iron in the organism, WHO recommends its measurement to determining prevalence of anemia as screening for iron deficiency (ID) despite that they recognize that anemia is not a specific indication of ID...
  • Publicación
    Doseresponse effect of black maca (Lepidium meyenii) in mice with memory impairment induced by ethanol
    (Elsevier, 2011)
    Rubio J.
    ;
    Yucra S.
    ;
    Gasco M.
    ;
    Gonzales G.F.
    Previous studies have shown that black variety of maca has beneficial effects on learning and memory in experimental animal models. The present study aimed to determine whether the hydroalcoholic extract of black maca (BM) showed a dose–response effect in mice treated with ethanol 20% (EtOH) as a model of memory impairment. Mice were divided in the following groups: control, EtOH, ascorbic acid (AA) and 0.125, 0.25, 0.50 and 1.00 g/kg of BM plus EtOH. All treatments were orally administered for 28 days. Open field test was performed to determine locomotor activity and water Morris maze was done to determine spatial memory. Also, total polyphenol content in the hydroalcoholic extract of BM was determined (0.65 g pyrogallol/100 g). Mice treated with EtOH took more time to find the hidden platform than control during escape acquisition trials; meanwhile, AA and BM reversed the effect of EtOH. In addition, AA and BM ameliorated the deleterious effect of EtOH during the probe trial. Correlation analyses showed that the effect of BM a dose-dependent behavior. Finally, BM improved experimental memory impairment induced by ethanol in a dose–response manner due, in part, to its content of polyphenolic compounds.