3.2 Pasantías y ponencias

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https://hdl.handle.net/20.500.12390/361

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Reconstitution properties of biologically active polymersomes after cryogenic freezing and a freeze-drying process

(Royal Society of Chemistry, 2018)
Ccorahua R.
;
Moreno S.
;
Gumz H.
;
Sahre K.
;
Voit B.
;
Appelhans D.

Reconstitution of biologically active polymersomes from the frozen or solid state into any fluid state is still a challenging issue for the design of new biological experiments and for the formulation of therapeutic agents. To gain knowledge about the reconstitution of pH-responsive and photo-crosslinked polymersomes, surface-functionalized and enzyme-containing polymersomers were cryogenically frozen ( 20 C) or freeze-dried with inulin as the lyoprotectant (0.1% w/v) and stored for a defined time period. Reconstituting those polymersomes in solution by thawing or a re-dispersing process revealed their original physical properties as well as their function as a pH-switchable enzymatic nanoreactor.