In Vivo Estimation of Attenuation and Backscatter Coefficients From Human Thyroids Rouyer, J es_PE Cueva, T es_PE Yamamoto, T es_PE Portal, A es_PE Lavarello, RJ es_PE 2024-05-30T23:13:38Z 2024-05-30T23:13:38Z 2016
dc.description.abstract Fine-needle aspiration (FNA) remains the gold standard for the diagnosis of thyroid cancer. However, currently, a large number of FNA biopsies result in negative or undetermined diagnosis, which suggests that better noninvasive tools are needed for the clinical management of thyroid cancer. Spectral-based quantitative ultrasound (QUS) characterizations may offer a better diagnostic management as previously demonstrated in mouse cancer models ex vivo. As a first step toward understanding the potential of QUS markers for thyroid disease management, this paper deals with the spectral-based QUS estimation of healthy human thyroids in vivo. Twenty volunteers were inspected by a trained radiologist using two ultrasonic imaging systems, which allowed them to acquire radio-frequency data spanning the 3-16-MHz frequency range. Estimates of attenuation coefficient slope (ACS) using the spectral logarithmic difference method had an average value of 1.69 dB/(cm·MHz) with a standard deviation of 0.28 dB/cm·MHz. Estimates of backscatter coefficient (BSC) using the reference-phantom method had an average value of 0.18 sr -1 · cm -1 over the useful frequency range. The intersubject variability when estimating BSCs was less than 1.5 dB over the analysis frequency range. Further, the effectiveness of three scattering models (i.e., fluid sphere, Gaussian, and exponential form factors) when fitting the experimentally estimated BSCs was assessed. The exponential form factor was found to provide the best overall goodness of fit (R 2 = 0.917), followed by the Gaussian (R 2 = 0.807) and the fluid-sphere models (R 2 = 0.752). For all scattering models used in this study, average estimates of the effective scatterer diameter were between 44 and 56 μm. Overall, an excellent agreement in the estimated attenuation and BSCs with both scanners was exhibited.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.isi 384323300004
dc.language.iso eng
dc.publisher Institute of Electrical and Electronics Engineers
dc.relation.ispartof IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control
dc.rights info:eu-repo/semantics/openAccess
dc.subject Form factor
dc.subject Attenuation coefficient es_PE
dc.subject Backscatter coefficient es_PE
dc.title In Vivo Estimation of Attenuation and Backscatter Coefficients From Human Thyroids
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication