Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming Sanchez-Castro E.E. es_PE Pajuelo-Reyes C. es_PE Tejedo R. es_PE Soria-Juan B. es_PE Tapia-Limonchi R. es_PE Andreu E. es_PE Hitos A.B. es_PE Martin F. es_PE Cahuana G.M. es_PE Guerra-Duarte C. es_PE de Assis T.C.S. es_PE Bedoya F.J. es_PE Soria B. es_PE Chávez-Olórtegui C. es_PE Tejedo J.R. es_PE 2024-05-30T23:13:38Z 2024-05-30T23:13:38Z 2021
dc.description.abstract Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable to completely neutralize the local venom effects. Local damage, such as dermonecrosis and myonecrosis, can lead to permanent sequelae with physical, social, and psychological implications. The strong inflammatory process induced by snake venoms is associated with poor tissue regeneration, in particular the lack of or reduced skeletal muscle regeneration. Mesenchymal stromal cells (MSCs)-based therapies have shown both anti-inflammatory and pro-regenerative properties. We postulate that using allogeneic MSCs or their cell-free products can induce skeletal muscle regeneration in snakebite victims, improving all the three steps of the skeletal muscle regeneration process, mainly by anti-inflammatory activity, paracrine effects, neovascularization induction, and inhibition of tissue damage, instrumental for microenvironment remodeling and regeneration. Since snakebite envenoming occurs mainly in areas with poor healthcare, we enlist the principles and potential of MSCs-based therapies and discuss regulatory issues, good manufacturing practices, transportation, storage, and related-procedures that could allow the administration of these therapies, looking forward to a safe and cost-effective treatment for a so far unsolved and neglected health problem. © Copyright © 2021 Sanchez-Castro, Pajuelo-Reyes, Tejedo, Soria-Juan, Tapia-Limonchi, Andreu, Hitos, Martin, Cahuana, Guerra-Duarte, de Assis, Bedoya, Soria, Chávez-Olórtegui and Tejedo.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.scopus 2-s2.0-85100912684
dc.language.iso eng
dc.publisher Frontiers Media S.A.
dc.relation.ispartof Frontiers in Immunology
dc.rights info:eu-repo/semantics/openAccess
dc.subject snakebite
dc.subject advanced therapy medicinal products es_PE
dc.subject envenoming es_PE
dc.subject mesenchymal stromal cells es_PE
dc.subject muscle regeneration es_PE
dc.title Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication