Publicación:
A mixture of extracts from Peruvian plants (black maca and yacon) improves sperm count and reduced glycemia in mice with streptozotocin-induced diabetes

dc.contributor.author Gonzales G.F. es_PE
dc.contributor.author Gonzales-Castañeda C. es_PE
dc.contributor.author Gasco M. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2013
dc.description.abstract We investigated the effect of two extracts from Peruvian plants given alone or in a mixture on sperm count and glycemia in streptozotocin-diabetic mice. Normal or diabetic mice were divided in groups receiving vehicle, black maca (Lepidium meyenii), yacon (Smallanthus sonchifolius) or three mixtures of extracts black maca/yacon (90/10, 50/50 and 10/90%). Normal or diabetic mice were treated for 7 d with each extract, mixture or vehicle. Glycemia, daily sperm production (DSP), epididymal and vas deferens sperm counts in mice and polyphenol content, and antioxidant activity in each extract were assessed. Black maca (BM), yacon and the mixture of extracts reduced glucose levels in diabetic mice. Non-diabetic mice treated with BM and yacon showed higher DSP than those treated with vehicle (p < 0.05). Diabetic mice treated with BM, yacon and the mixture maca/yacon increased DSP, and sperm count in vas deferens and epididymis with respect to non-diabetic and diabetic mice treated with vehicle (p < 0.05). Yacon has 3.05 times higher polyphenol content than in maca, and this was associated with higher antioxidant activity. The combination of two extracts improved glycemic levels and male reproductive function in diabetic mice. Streptozotocin increased 1.43 times the liver weight that was reversed with the assessed plants extracts. In summary, streptozotocin-induced diabetes resulted in reduction in sperm counts and liver damage. These effects could be reduced with BM, yacon and the BM+yacon mixture.
dc.description.sponsorship Fondo Nacional de Desarrollo Científico y Tecnológico - Fondecyt
dc.identifier.doi https://doi.org/10.3109/15376516.2013.785656
dc.identifier.scopus 2-s2.0-84883434116
dc.identifier.uri https://hdl.handle.net/20.500.12390/490
dc.language.iso eng
dc.publisher Taylor & Francis
dc.relation.ispartof Toxicology Mechanisms and Methods
dc.rights info:eu-repo/semantics/openAccess
dc.subject unclassified drug
dc.subject antioxidant es_PE
dc.subject glucose es_PE
dc.subject Lepidium meyenii extract es_PE
dc.subject plant extract es_PE
dc.subject polyphenol es_PE
dc.subject Smallanthus sonchifolius extract es_PE
dc.subject streptozocin es_PE
dc.subject animal experiment es_PE
dc.subject antioxidant activity es_PE
dc.subject article es_PE
dc.subject controlled study es_PE
dc.subject drug effect es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.07
dc.title A mixture of extracts from Peruvian plants (black maca and yacon) improves sperm count and reduced glycemia in mice with streptozotocin-induced diabetes
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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