Publicación:
Effectiveness of a malaria surveillance strategy based on active case detection during high transmission season in the Peruvian Amazon

dc.contributor.author Moreno-Gutierrez D. es_PE
dc.contributor.author Llanos-Cuentas A. es_PE
dc.contributor.author Barboza J.L. es_PE
dc.contributor.author Contreras-Mancilla J. es_PE
dc.contributor.author Gamboa D. es_PE
dc.contributor.author Rodriguez H. es_PE
dc.contributor.author Carrasco-Escobar G. es_PE
dc.contributor.author Boreux R. es_PE
dc.contributor.author Hayette M.-P. es_PE
dc.contributor.author Beutels P. es_PE
dc.contributor.author Speybroeck N. es_PE
dc.contributor.author Rosas-Aguirre A. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2018
dc.description.abstract Background: Faced with the resurgence of malaria, malaria surveillance in the Peruvian Amazon incorporated consecutive active case detection (ACD) interventions using light microscopy (LM) as reactive measure in communities with an unusual high number of cases during high transmission season (HTS). We assessed the effectiveness in malaria detection of this local ACD-based strategy. Methods: A cohort study was conducted in June–July 2015 in Mazan, Loreto. Four consecutive ACD interventions at intervals of 10 days were conducted in four riverine communities (Gamitanacocha, Primero de Enero, Libertad and Urco Miraño). In each intervention, all inhabitants were visited at home, and finger-prick blood samples collected for immediate diagnosis by LM and on filter paper for later analysis by quantitative real-time polymerase chain reaction (qPCR). Effectiveness was calculated by dividing the number of malaria infections detected using LM by the number of malaria infections detected by delayed qPCR. Results: Most community inhabitants (88.1%, 822/933) were present in at least one of the four ACD interventions. A total of 451 infections were detected by qPCR in 446 participants (54.3% of total participants); five individuals had two infections. Plasmodium vivax was the predominant species (79.8%), followed by P. falciparum (15.3%) and P. vivax-P. falciparum co-infections (4.9%). Most qPCR-positive infections were asymptomatic (255/448, 56.9%). The ACD-strategy using LM had an effectiveness of 22.8% (detection of 103 of the total qPCR-positive infections). Children aged 5–14 years, and farming as main economic activity were associated with P. vivax infections. Conclusions: Although the ACD-strategy using LM increased the opportunity of detecting and treating malaria infections during HTS, the number of detected infections was considerably lower than the real burden of infections (those detected by qPCR)
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.3390/ijerph15122670
dc.identifier.scopus 2-s2.0-85057522533
dc.identifier.uri https://hdl.handle.net/20.500.12390/585
dc.language.iso eng
dc.publisher MDPI AG
dc.relation.ispartof International Journal of Environmental Research and Public Health
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject primaquine
dc.subject artesunate es_PE
dc.subject chloroquine es_PE
dc.subject mefloquine es_PE
dc.subject adolescent es_PE
dc.subject adult es_PE
dc.subject agricultural worker es_PE
dc.subject Article es_PE
dc.subject asymptomatic infection es_PE
dc.subject blood sampling es_PE
dc.subject child es_PE
dc.subject cohort analysis es_PE
dc.subject community program es_PE
dc.subject community sample es_PE
dc.subject controlled study es_PE
dc.subject disease surveillance es_PE
dc.subject female es_PE
dc.subject human es_PE
dc.subject major clinical study es_PE
dc.subject malaria es_PE
dc.subject malaria falciparum es_PE
dc.subject male es_PE
dc.subject microscopy es_PE
dc.subject mixed infection es_PE
dc.subject nonhuman es_PE
dc.subject parasite transmission es_PE
dc.subject Peru es_PE
dc.subject Plasmodium falciparum es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.title Effectiveness of a malaria surveillance strategy based on active case detection during high transmission season in the Peruvian Amazon
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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