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Delimitation of the upstream region of NFKBIA gene associated with HTLV-1-associated myelopathy/tropical spastic paraparesis using candidate Tag-SNPs in Peruvian HTLV-1 infected individuals
Delimitation of the upstream region of NFKBIA gene associated with HTLV-1-associated myelopathy/tropical spastic paraparesis using candidate Tag-SNPs in Peruvian HTLV-1 infected individuals
| dc.contributor.author | Posadas A.E. | es_PE |
| dc.contributor.author | Rosado J.J. | es_PE |
| dc.contributor.author | Gotuzzo E. | es_PE |
| dc.contributor.author | Talledo M.J. | es_PE |
| dc.date.accessioned | 2024-05-30T23:13:38Z | |
| dc.date.available | 2024-05-30T23:13:38Z | |
| dc.date.issued | 2019 | |
| dc.description | This study was supported by the FONDECYT -Peru and Directorate General for Development Cooperation of the Belgian Government through the framework agreement with the Institute of Tropical Medicine of Antwerp and through the Flemish Interuniversity Council (VLIR). | |
| dc.description.abstract | In Peru, it is estimated that about 150 000-400 000 people carry the Human T-lymphotropic virus 1 (HTLV-1). Only 10% of HTLV-1 carries develop complications related to HTLV-1. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic disabling inflammatory disease affecting the spinal cord. HAM/TSP produces principally weakness in the lower limbs and bladder disturbances, among other complications. In a previous study, our group identified three SNPs (rs3138053, rs2233406, and rs3138045) located in the promoter region of the NFKBIA gene associated with HAM/TSP. This study aimed to analyze the association between four Tag-SNPs (rs10148482, rs17103274, rs17103282, and rs762009) located in the upstream region of the NFKBIA gene and HAM/TSP, and to delimit the linkage disequilibrium zone in the upstream region of the NFBKIA gene associated with HAM/TSP. The tetra-primers ARMS-PCR technique was used to genotype 4 Tag-SNPs on 140 HAM/TSP patients and 258 asymptomatic carriers. The SNP rs17103282 showed a deviation from Hardy-Weinberg equilibrium (p < .0001). Neither of three Tag-SNPs showed an association with HAM/TSP (P > .05). No linkage disequilibrium between four Tag-SNPs evaluated in this study and previous ones was observed. Here we show the region located in the upstream region of the NFKBIA gene highly associated with HAM/TSP disease in patients infected with HTLV-1 from Lima, Peru. © 2019 Elsevier B.V. | |
| dc.description.sponsorship | Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec | |
| dc.identifier.doi | https://doi.org/10.1016/j.meegid.2019.103929 | |
| dc.identifier.scopus | 2-s2.0-85068425780 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12390/2298 | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier B.V. | |
| dc.relation.ispartof | Infection, Genetics and Evolution | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | SNP | |
| dc.subject | Genetic association studies | es_PE |
| dc.subject | HAM/TSP | es_PE |
| dc.subject | Human T-cell leukemia virus 1 | es_PE |
| dc.subject | Linkage disequilibrium | es_PE |
| dc.subject.ocde | http://purl.org/pe-repo/ocde/ford#3.03.09 | |
| dc.title | Delimitation of the upstream region of NFKBIA gene associated with HTLV-1-associated myelopathy/tropical spastic paraparesis using candidate Tag-SNPs in Peruvian HTLV-1 infected individuals | |
| dc.type | info:eu-repo/semantics/article | |
| dspace.entity.type | Publication |