Publicación:
Extended-spectrum beta-lactamase-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru
Extended-spectrum beta-lactamase-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru
| dc.contributor.author | Benavides J.A. | es_PE |
| dc.contributor.author | Shiva C. | es_PE |
| dc.contributor.author | Virhuez M. | es_PE |
| dc.contributor.author | Tello C. | es_PE |
| dc.contributor.author | Appelgren A. | es_PE |
| dc.contributor.author | Vendrell J. | es_PE |
| dc.contributor.author | Solassol J. | es_PE |
| dc.contributor.author | Godreuil S. | es_PE |
| dc.contributor.author | Streicker D.G. | es_PE |
| dc.date.accessioned | 2024-05-30T23:13:38Z | |
| dc.date.available | 2024-05-30T23:13:38Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Antibiotic resistance mediated by bacterial production of extended-spectrum beta-lactamase (ESBL) is a global threat to public health. ESBL resistance is most commonly hospital-acquired; however, infections acquired outside of hospital settings have raised concerns over the role of livestock and wildlife in the zoonotic spread of ESBL-producing bacteria. Only limited data are available on the circulation of ESBL-producing bacteria in animals. Here, we report ESBL-producing Escherichia coli in wild common vampire bats Desmodus rotundus and livestock near Lima, Peru. Molecular analyses revealed that most of this resistance resulted from the expression of blaCTX-M-15 genes carried by plasmids, which are disseminating worldwide in hospital settings and have also been observed in healthy children of Peru. Multilocus sequence typing showed a diverse pool of E. coli strains carrying this resistance that were not always host species-specific, suggesting sharing of strains between species or infection from a common source. This study shows widespread ESBL resistance in wild and domestic animals, supporting animal communities as a potential source of resistance. Future work is needed to elucidate the role of bats in the dissemination of antibiotic-resistant strains of public health importance and to understand the origin of the observed resistance. | |
| dc.description.sponsorship | Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec | |
| dc.identifier.doi | https://doi.org/10.1111/zph.12456 | |
| dc.identifier.scopus | 2-s2.0-85044351587 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12390/614 | |
| dc.language.iso | eng | |
| dc.publisher | Wiley-VCH Verlag | |
| dc.relation.ispartof | Zoonoses and Public Health | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | unclassified drug | |
| dc.subject | beta lactamase CTX M | es_PE |
| dc.subject | beta lactamase CTX M15 | es_PE |
| dc.subject | antiinfective agent | es_PE |
| dc.subject | beta lactamase | es_PE |
| dc.subject | antibiotic resistance | es_PE |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.04.00 | |
| dc.title | Extended-spectrum beta-lactamase-producing Escherichia coli in common vampire bats Desmodus rotundus and livestock in Peru | |
| dc.type | info:eu-repo/semantics/article | |
| dspace.entity.type | Publication |