Publicación:
Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c
Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c
| dc.contributor.author | Rosas-Cruz G.P. | es_PE |
| dc.contributor.author | Silva-Correa C.R. | es_PE |
| dc.contributor.author | Calderón-Peña A.A. | es_PE |
| dc.contributor.author | Villarreal-La Torre V.E. | es_PE |
| dc.contributor.author | Aspajo-Villalaz C.L. | es_PE |
| dc.contributor.author | Cruzado-Razco J.L. | es_PE |
| dc.contributor.author | Rosario-Chávarri J.D. | es_PE |
| dc.contributor.author | Rodríguez-Soto J.C. | es_PE |
| dc.contributor.author | Pretel-Sevillano O.E. | es_PE |
| dc.contributor.author | Sagástegui-Guarniz W.A. | es_PE |
| dc.contributor.author | González-Siccha A.D. | es_PE |
| dc.date.accessioned | 2024-05-30T23:13:38Z | |
| dc.date.available | 2024-05-30T23:13:38Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Background: Solanum tuberosum L. is an Andean tuber that is mainly characterized by its antioxidant properties. Objective: To evaluate the healing activity of an S. tuberosum-based ointment on wounds induced in mice. Material and methods: Ethanolic extracts of peel and pulp of tubers of S. tuberosum "Tumbay yellow potato"were prepared, which were incorporated into 1% and 2% ointment formulations. Mus musculus Balb/c with induced wound were distributed in the following working groups: Group I (Negative Control), Group II (Positive Control: Neomycin, Polymyxin B and Bacitracin Ointment) and Groups III and IV (Ointment at 1 % and 2% of S. tuberosum extract, respectively), daily administration of topical treatments were carried out for 07 days. Wound closure was determined during the experimentation time, then euthanized with sodium pentobarbital 60 mg/kg b.w. (i.p.) to obtain skin samples for histopathological analysis. Results: Groups III and IV showed that better evidence of wound closure and scarring in the histopathological analysis, the greatest effect being in Group IV. Conclusions: S. tuberosum ointments show healing activity in induced wounds in mice, the most effective treatment being the 2% ointment formulation. © 2020 Phcogj.Com. | |
| dc.description.sponsorship | Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec | |
| dc.identifier.doi | https://doi.org/10.5530/PJ.2020.12.175 | |
| dc.identifier.scopus | 2-s2.0-85092318118 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12390/2437 | |
| dc.language.iso | eng | |
| dc.publisher | EManuscript Technologies | |
| dc.relation.ispartof | Pharmacognosy Journal | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | Yellow potato | |
| dc.subject | Histology | es_PE |
| dc.subject | Skin | es_PE |
| dc.subject | Solanum tuberosum | es_PE |
| dc.subject | Wound healing | es_PE |
| dc.subject.ocde | http://purl.org/pe-repo/ocde/ford#3.02.27 | |
| dc.title | Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c | |
| dc.type | info:eu-repo/semantics/article | |
| dspace.entity.type | Publication |