Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c Rosas-Cruz G.P. es_PE Silva-Correa C.R. es_PE Calderón-Peña A.A. es_PE Villarreal-La Torre V.E. es_PE Aspajo-Villalaz C.L. es_PE Cruzado-Razco J.L. es_PE Rosario-Chávarri J.D. es_PE Rodríguez-Soto J.C. es_PE Pretel-Sevillano O.E. es_PE Sagástegui-Guarniz W.A. es_PE González-Siccha A.D. es_PE 2024-05-30T23:13:38Z 2024-05-30T23:13:38Z 2020
dc.description.abstract Background: Solanum tuberosum L. is an Andean tuber that is mainly characterized by its antioxidant properties. Objective: To evaluate the healing activity of an S. tuberosum-based ointment on wounds induced in mice. Material and methods: Ethanolic extracts of peel and pulp of tubers of S. tuberosum "Tumbay yellow potato"were prepared, which were incorporated into 1% and 2% ointment formulations. Mus musculus Balb/c with induced wound were distributed in the following working groups: Group I (Negative Control), Group II (Positive Control: Neomycin, Polymyxin B and Bacitracin Ointment) and Groups III and IV (Ointment at 1 % and 2% of S. tuberosum extract, respectively), daily administration of topical treatments were carried out for 07 days. Wound closure was determined during the experimentation time, then euthanized with sodium pentobarbital 60 mg/kg b.w. (i.p.) to obtain skin samples for histopathological analysis. Results: Groups III and IV showed that better evidence of wound closure and scarring in the histopathological analysis, the greatest effect being in Group IV. Conclusions: S. tuberosum ointments show healing activity in induced wounds in mice, the most effective treatment being the 2% ointment formulation. © 2020 Phcogj.Com.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.scopus 2-s2.0-85092318118
dc.language.iso eng
dc.publisher EManuscript Technologies
dc.relation.ispartof Pharmacognosy Journal
dc.rights info:eu-repo/semantics/openAccess
dc.subject Yellow potato
dc.subject Histology es_PE
dc.subject Skin es_PE
dc.subject Solanum tuberosum es_PE
dc.subject Wound healing es_PE
dc.title Wound Healing Activity of an Ointment from Solanum tuberosum L. "Tumbay Yellow Potato" on Mus musculus Balb/c
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication