Publicación:
Multifunctional in vitro bioactive properties: Antioxidant, antidiabetic, and antihypertensive of protein hydrolyzates from tarwi (Lupinus mutabilis Sweet) obtained by enzymatic biotransformation
Multifunctional in vitro bioactive properties: Antioxidant, antidiabetic, and antihypertensive of protein hydrolyzates from tarwi (Lupinus mutabilis Sweet) obtained by enzymatic biotransformation
| dc.contributor.author | Chirinos, Rosana | es_PE |
| dc.contributor.author | Cerna, Elisabeth | es_PE |
| dc.contributor.author | Pedreschi, Romina | es_PE |
| dc.contributor.author | Calsin, Marienela | es_PE |
| dc.contributor.author | Aguilar-Galvez, Ana | es_PE |
| dc.contributor.author | Campos, David | es_PE |
| dc.date.accessioned | 2024-05-30T23:13:38Z | |
| dc.date.available | 2024-05-30T23:13:38Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Background and objectives: Tarwi is a legume that grows in the Andean region of Peru. This grain is characterized by having a high protein content (similar to 42%). In order to generate added-value products from this resource, the possibility of obtaining tarwi protein hydrolyzates (TPH) with in vitro bioactive properties was evaluated using Alcalase, Neutrase, and Flavourzyme enzymes, acting alone or in combination for up to 240 min. The in vitro evaluated properties were as follows: antioxidant (ABTS assay), antidiabetic (alpha-amylase, alpha-glucosidase and dipeptidyl peptidase IV (DPP-IV) inhibition), and antihypertensive (angiotensin-converting enzyme-I (ACE) inhibition). Findings: The TPH obtained from the different enzyme treatments exhibited important antioxidant, antidiabetic (specially for DPP-IV inhibition), and antihypertensive properties. One-stage treatment using Alcalase for 240 min and two sequential stage treatments with Alcalase-Neutrase for 180 min presented the highest ABTS antioxidant activity and lowest IC50 values for DPP-IV and ACE corresponding to 2.0-1.95 mu mol TE/mg, 2.14-2.61 and 0.16-0.11 mg/ml, respectively. Conclusions: The results of this research demonstrate that TPH exhibit in vitro multifunctional bioactive properties. Significance and novelty: TPH could potentially be used in the prevention or management of chronic diseases related to the development of oxidative processes, diabetes, and hypertension. | |
| dc.description.sponsorship | Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec | |
| dc.identifier.doi | https://doi.org/10.1002/cche.10382 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12390/2818 | |
| dc.language.iso | eng | |
| dc.publisher | Wiley | |
| dc.relation.ispartof | CEREAL CHEMISTRY | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.subject | Organic Chemistry | |
| dc.subject | Food Science | es_PE |
| dc.subject.ocde | http://purl.org/pe-repo/ocde/ford#2.11.01 | |
| dc.title | Multifunctional in vitro bioactive properties: Antioxidant, antidiabetic, and antihypertensive of protein hydrolyzates from tarwi (Lupinus mutabilis Sweet) obtained by enzymatic biotransformation | |
| dc.type | info:eu-repo/semantics/article | |
| dspace.entity.type | Publication |