Publicación:
Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

dc.contributor.author Abascal E. es_PE
dc.contributor.author Herranz M. es_PE
dc.contributor.author Acosta F. es_PE
dc.contributor.author Agapito J. es_PE
dc.contributor.author Cabibbe A.M. es_PE
dc.contributor.author Monteserin J. es_PE
dc.contributor.author Ruiz Serrano M.J. es_PE
dc.contributor.author Gijón P. es_PE
dc.contributor.author Fernández-González F. es_PE
dc.contributor.author Lozano N. es_PE
dc.contributor.author Chiner-Oms Á. es_PE
dc.contributor.author Cáceres T. es_PE
dc.contributor.author Pintado P.G. es_PE
dc.contributor.author Acín E. es_PE
dc.contributor.author Valencia E. es_PE
dc.contributor.author Muñoz P. es_PE
dc.contributor.author Comas I. es_PE
dc.contributor.author Cirillo D.M. es_PE
dc.contributor.author Ritacco V. es_PE
dc.contributor.author Gotuzzo E. es_PE
dc.contributor.author García de Viedma D. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2020
dc.description.abstract It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR–clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002–5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection. © 2020, The Author(s).
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.1038/s41598-020-59373-w
dc.identifier.scopus 2-s2.0-85079612900
dc.identifier.uri https://hdl.handle.net/20.500.12390/2447
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Scientific Reports
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Humans
dc.subject Antitubercular Agents es_PE
dc.subject Bacterial Typing Techniques es_PE
dc.subject Coinfection es_PE
dc.subject Drug Resistance es_PE
dc.subject.ocde http://purl.org/pe-repo/ocde/ford#3.03.08
dc.title Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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