Association between SLC11A1 polymorphisms and susceptibility to different clinical forms of tuberculosis in the Peruvian population

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Taype C.A.
Castro J.C.
Accinelli R.A.
Herrera-Velit P.
Shaw M.A.
Espinoza J.R.
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Polymorphism in SLC11A1 has been implicated in host susceptibility to tuberculosis. We have studied associations between INT4, D543N, and 3′UTR polymorphisms of SLC11A1 and different clinical forms of TB. Analysis used 507 patients with pulmonary TB, 123 with extra pulmonary TB and 513 controls. INT4 and D543N showed allelic association with pulmonary TB (P = 0.02 and 0.03 respectively). INT4–D543N–3′UTR haplotypes showed an association with pulmonary TB (P = 0.03). No association of SLC11A1 with miliary TB was observed, and a possible association of D543N to the pleural form (P = 0.08) was suggested. These results support association between SLC11A1 and TB, particularly to the common pulmonary form.
This study was supported by Proyecto Vig?´a MINSA/USAID, Lima; Premio Anual de Medicina Francisco Tejada y Sem?´ramis Rea´tegui (Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, UPCH), Lima; Fundacio´n Instituto Hipo´lito Unanue, Lima and Consejo Nacional de Ciencia y Tecnolog?´a (CONCYTEC), Lima-Peru´. CT received support from CONCYETC, the Agreement between Consortium of Francophones Universities of Belgium (CIUF) and UPCH, and the Fundacio´n Cristina e Ismael Cobia´n (Facultad de Ciencias y Filosof?´a Alberto Cazorla Ta´lleri, UPCH). We are very grateful to Dr. Rupert Quinnell for valuable suggestions to this paper.
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unclassified drug, natural resistance associated macrophage protein 1, solute carrier family 11 member A1 protein, 3 untranslated region, adult, allele, article, controlled study, extrapulmonary tuberculosis, gene frequency