Publicación:
Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts

Página de artículo simple
dc.contributor.author Céline V. es_PE
dc.contributor.author Adriana P. es_PE
dc.contributor.author Eric D. es_PE
dc.contributor.author Joaquina A. es_PE
dc.contributor.author Yannick E. es_PE
dc.contributor.author Augusto L.F. es_PE
dc.contributor.author Rosario R. es_PE
dc.contributor.author Dionicia G. es_PE
dc.contributor.author Michel S. es_PE
dc.contributor.author Denis C. es_PE
dc.contributor.author Geneviève B. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2009
dc.description The authors gratefully acknowledge the financial assistance of CONCYTEC from Peru and DSF-IRD (JEAI) from France. We express our thanks to members of the Yanesha community who were willing to share with us their knowledge about medicinal plants. The authors are grateful to Candy Ruiz from LID-UPCH, for technical assistance in plants extractions. Céline Valadeau, Adriana Pabon and Denis Castillo received grants from the Institut Franc¸ ais des Etudes Andines, Colciencias and the Belgian technical cooperation respectively. Part of this work was supported by a grant from the International Foundation for Sciences attributed to Dionicia Gamboa
dc.description.abstract Aim of the study: Ninety-four ethanolic extracts of plants used medicinally by the Yanesha, an Amazonian Peruvian ethnic group, for affections related to leishmaniasis and malaria were screened in vitro against Leishmania amazonensis amastigotes and against a Plasmodium falciparum chloroquine resistant strain. Materials and methods: The viability of Leishmania amazonensis amastigote stages was assessed by the reduction of tetrazolium salt (MTT) while the impact on Plasmodium falciparum was determined by measuring the incorporation of radio-labelled hypoxanthine. Results and conclusions: Six plant species displayed good activity against Plasmodium falciparum chloroquine resistant strain (IC50 < 10 μg/ml): a Monimiaceae, Siparuna aspera (Ruiz & Pavon), A. DC., two Zingiberaceae, Renealmia thyrsoidea (Ruiz & Pavon) Poepp. & Endl. and Renealmia alpinia (Rottb.), two Piperaceae (Piper aduncum L. and Piper sp.) and the leaves of Jacaranda copaia (Aubl.) D. Don (Bignoniaceae). Eight species displayed interesting leishmanicidal activities (IC50 < 10 μg/ml): Carica papaya L. (Caricaceae), Piper dennisii Trel (Piperaceae), Hedychium coronarium J. König (Zingiberaceae), Cestrum racemosum Ruiz & Pav. (Solanaceae), Renealmia alpinia (Rottb.) Zingiberaceae, Lantana sp. (Verbenaceae), Hyptis lacustris A. St.-Hil. ex Benth. (Lamiaceae) and Calea montana Klat. (Asteraceae). Most of them are used against skin affections by Yanesha people. Results are discussed herein, according to the traditional use of the plants and compared with data obtained from the literature.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.1016/j.jep.2009.03.041
dc.identifier.scopus 2-s2.0-67349122667
dc.identifier.uri https://hdl.handle.net/20.500.12390/716
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Journal of Ethnopharmacology
dc.rights info:eu-repo/semantics/openAccess
dc.subject hypoxanthine
dc.subject alcohol es_PE
dc.subject antileishmanial agent es_PE
dc.subject antimalarial agent es_PE
dc.subject Calea montana extract es_PE
dc.subject Carica papaya extract es_PE
dc.subject Cestrum racemosum extract es_PE
dc.subject chloroquine es_PE
dc.subject Hedychium coronarium extract es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.title Medicinal plants from the Yanesha (Peru): Evaluation of the leishmanicidal and antimalarial activity of selected extracts
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
Archivos
Colecciones
1.1 Eventos institucionales
 6.1 Proyectos de investigación científica