Publicación:
Pvmsp8 as a novel plasmodium vivax malaria sero-marker for the peruvian amazon
Pvmsp8 as a novel plasmodium vivax malaria sero-marker for the peruvian amazon
| dc.contributor.author | Villasis E. | es_PE |
| dc.contributor.author | Garro K. | es_PE |
| dc.contributor.author | Rosas-Aguirre A. | es_PE |
| dc.contributor.author | Rodriguez P. | es_PE |
| dc.contributor.author | Rosado J. | es_PE |
| dc.contributor.author | Gave A. | es_PE |
| dc.contributor.author | Guzman-Guzman M. | es_PE |
| dc.contributor.author | Manrique P. | es_PE |
| dc.contributor.author | White M. | es_PE |
| dc.contributor.author | Speybroeck N. | es_PE |
| dc.contributor.author | Vinetz J.M. | es_PE |
| dc.contributor.author | Torres K. | es_PE |
| dc.contributor.author | Gamboa D. | es_PE |
| dc.date.accessioned | 2024-05-30T23:13:38Z | |
| dc.date.available | 2024-05-30T23:13:38Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | The measurement of recent malaria exposure can support malaria control efforts. This study evaluated serological responses to an in-house Plasmodium vivax Merozoite Surface Protein 8 (PvMSP8) expressed in a Baculovirus system as sero-marker of recent exposure to P. vivax (Pv) in the Peruvian Amazon. In a first evaluation, IgGs against PvMSP8 and PvMSP10 proteins were measured by Luminex in a cohort of 422 Amazonian individuals with known history of Pv exposure (monthly data of infection status by qPCR and/or microscopy over five months). Both serological responses were able to discriminate between exposed and non-exposed individuals in a good manner, with slightly higher performance of anti-PvMSP10 IgGs (area under the curve AUC = 0.78 [95% CI = 0.72–0.83]) than anti-PvMSP8 IgGs (AUC = 0.72 [95% CI = 0.67–0.78]) (p = 0.01). In a second evaluation, the analysis by ELISA of 1251 plasma samples, collected during a population-based cross-sectional survey, confirmed the good performance of anti-PvMSP8 IgGs for discriminating between individuals with Pv infection at the time of survey and/or with antecedent of Pv in the past month (AUC = 0.79 [95% CI = 0.74–0.83]). Anti-PvMSP8 IgG antibodies can be considered as a good biomarker of recent Pv exposure in low-moderate transmission settings of the Peruvian Amazon. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | |
| dc.description.sponsorship | Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec | |
| dc.identifier.doi | https://doi.org/10.3390/pathogens10030282 | |
| dc.identifier.scopus | 2-s2.0-85102554474 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12390/2375 | |
| dc.language.iso | eng | |
| dc.publisher | MDPI AG | |
| dc.relation.ispartof | Pathogens | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject | PvMSP8 | |
| dc.subject | Antibodies | es_PE |
| dc.subject | ELISA | es_PE |
| dc.subject | Luminex | es_PE |
| dc.subject | Malaria | es_PE |
| dc.subject | P. vivax | es_PE |
| dc.subject.ocde | http://purl.org/pe-repo/ocde/ford#3.03.09 | |
| dc.title | Pvmsp8 as a novel plasmodium vivax malaria sero-marker for the peruvian amazon | |
| dc.type | info:eu-repo/semantics/article | |
| dspace.entity.type | Publication |