Publicación:
Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice

Página de artículo simple
dc.contributor.author Rubio J. es_PE
dc.contributor.author Dang H. es_PE
dc.contributor.author Gong M. es_PE
dc.contributor.author Liu X. es_PE
dc.contributor.author Chen S.-l. es_PE
dc.contributor.author Gonzales G.F. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2007
dc.description Peng Bo, Hu Qin, Xiaming Wen, Yang Keli, Jiang Zhen and Sandra Yucra are acknowledged for their help in this study. Special thanks to the joint financial support for this work from the National Nature Science Foundation of China, NSFC in 2004 (30472016/C03020701) and from Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2005 and support for travel. Julio Rubio was on leave from the Universidad Peruana Cayetano Heredia, Peru (UPCH) through the Memorandum of Understanding between IMPLAD, CONCYTEC and UPCH.
dc.description.abstract Lepidium meyenii Walp. (Brassicaceae), known as Maca, is a Peruvian hypocotyl growing exclusively between 4000 and 4500 m altitude in the central Peruvian Andes, particularly in Junin plateau. Previously, Black variety of Maca showed to be more beneficial than other varieties of Maca on learning and memory in ovariectomized mice on the water finding test. The present study aimed to test two different doses of aqueous (0.50 and 2.00 g/kg) and hydroalcoholic (0.25 and 1.00 g/kg) extracts of Black Maca administered for 35 days on memory impairment induced by scopolamine (1 mg/kg body weight i.p.) in male mice. Memory and learning were evaluated using the water Morris maze and the step-down avoidance test. Brain acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities in brain were also determined. Both extracts of Black Maca significantly ameliorated the scopolamine-induced memory impairment as measured in both the water Morris maze and the step-down avoidance tests. Black Maca extracts inhibited AChE activity, whereas MAO activity was not affected. These results indicate that Black Maca improves scopolamine-induced memory deficits.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.1016/j.fct.2007.04.002
dc.identifier.scopus 2-s2.0-34547734440
dc.identifier.uri https://hdl.handle.net/20.500.12390/734
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Food and Chemical Toxicology
dc.rights info:eu-repo/semantics/openAccess
dc.subject treatment outcome
dc.subject acetylcholinesterase es_PE
dc.subject alcohol es_PE
dc.subject amine oxidase (flavin containing) es_PE
dc.subject Lepidium meyenii extract es_PE
dc.subject scopolamine es_PE
dc.subject animal experiment es_PE
dc.subject animal model es_PE
dc.subject animal tissue es_PE
dc.subject aqueous solution es_PE
dc.subject article es_PE
dc.subject avoidance behavior es_PE
dc.subject brain protection es_PE
dc.subject controlled study es_PE
dc.subject drug effect es_PE
dc.subject enzyme activity es_PE
dc.subject learning es_PE
dc.subject male es_PE
dc.subject maze test es_PE
dc.subject memory disorder es_PE
dc.subject mouse es_PE
dc.subject nonhuman es_PE
dc.subject treatment duration es_PE
dc.subject Acetylcholine es_PE
dc.subject Animals es_PE
dc.subject Avoidance Learning es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.07
dc.title Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
Archivos
Colecciones
1.1 Eventos institucionales
 6.1 Proyectos de investigación científica