Publicación:
Immediate skin test reactivity to common aeroallergens in patients with respiratory allergies: A comparative analysis of allergen-induced skin reactions and their histamine controls

Página de artículo simple
dc.contributor.author Lopez L.R. es_PE
dc.contributor.author Noriega Y. es_PE
dc.contributor.author Losno R. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 1988
dc.description From the Department of Microbiology (Immunology Section) Uni-versidad Peruana Cayetano Heredia, Lima, Peru. Supported in part by a grant from Consejo de Ciencia y Tecnologia (CONCYTEC) of Peru.
dc.description.abstract The results of the immediate skin test response to a panel of 16 common aeroallergens performed in a group of 659 consecutive patients with symptoms suggestive of a respiratory allergy wereanalyzed. A group of 108 healthy individuals served as control subjects. Ninety-four percent of the patients and 87% of the control subjects had at least one allergen-induced reaction (wheal22 by 2 mm). The prevalence of positive skin reactions to each aeroallergen was equally high in both groups. However, if a skin reaction is considered as positive only when anallergen-induced wheal is equal or larger compared to the SO% of the wheal obtained with the histamine control in that individual, 70% of the patients had positive skin reactions and only38% of the control subjects were positive (p < 0.051. Similarly, the prevalence rates to five aeroallergens (pollen, Fusarium, Mucor, Pullularia, and Curvularia) in the patient group were reduced to those levels observed with the control group, suggesting they are clinically less important. The age and not the sex influenced both the prevalence rates (p < 0.001) and the mean size (p < 0.01) of allergen and histamine-induced skin reactions. Lower prevalence rates and mean size values were observed in the youngest group (0 to 9 years). Moreover, thew }was an inverse relationship between lower skin reactivity, with younger subjects in their own patient population. These results indicate that patients and healthy individuals have similar mechanisms for skin reactivity. The size of the allergen-induced wheal reaction compared to the histamine-induced control wheal reaction appears to be an important consideration for the correct clinical interpretation of the results. The observation that there were more younger patients with lower skin reactivity suggests that other mechanisms not detected by skin testing may pie a role in the pathogenesis of respiratory allergies.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.1016/0091-6749(88)90882-2
dc.identifier.scopus 2-s2.0-0023895334
dc.identifier.uri https://hdl.handle.net/20.500.12390/803
dc.language.iso eng
dc.publisher Universidad Peruana Cayetano Heredia
dc.relation.ispartof The Journal of Allergy and Clinical Immunology
dc.rights info:eu-repo/semantics/openAccess
dc.subject skin test
dc.subject allergen es_PE
dc.subject adolescent es_PE
dc.subject adult es_PE
dc.subject age es_PE
dc.subject aged es_PE
dc.subject child es_PE
dc.subject controlled study es_PE
dc.subject female es_PE
dc.subject human es_PE
dc.subject major clinical study es_PE
dc.subject male es_PE
dc.subject priority journal es_PE
dc.subject respiratory tract allergy es_PE
dc.subject sex difference es_PE
dc.subject Adolescent es_PE
dc.subject Adult es_PE
dc.subject Age Factors es_PE
dc.subject Aged es_PE
dc.subject Air Pollutants es_PE
dc.subject Allergens es_PE
dc.subject Child es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.title Immediate skin test reactivity to common aeroallergens in patients with respiratory allergies: A comparative analysis of allergen-induced skin reactions and their histamine controls
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
Archivos
Colecciones
1.1 Eventos institucionales
 6.1 Proyectos de investigación científica