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Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital

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dc.contributor.author Flores-Paredes W. es_PE
dc.contributor.author Luque N. es_PE
dc.contributor.author Albornoz R. es_PE
dc.contributor.author Rojas, N. es_PE
dc.contributor.author Espinoza M. es_PE
dc.contributor.author Pons M.J. es_PE
dc.contributor.author Ruiz J. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2021
dc.description JR was supported by Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica (FONDECYT - Perú) within the “Proyecto de Mejoramiento y Ampliación de los Servicios del Sistema Nacional de Ciencia, Tecnología e Innovación Tecnológica" [contract: 08-2019-FONDECYT-BM-INC-INV"].
dc.description.abstract Backgound: The members of the so-called ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) are a frequent cause of severe infection, ranking among the most relevant causes of hospital infections. In Peru, few studies, often focused in a single ESKAPE microorganism, have been performed, but none providing an overall and comprehensive long-time analysis of the antibiotic resistance of ESKAPE microorganisms. In the present study, the evolution of antimicrobial resistance levels of ESKAPE microorganisms isolated during 2009 - 2010 (Period 1) and 2012 - 2014 (Period 2) in a IV-level hospital in Lima was analyzed. Materials and Methods: ESKAPE microorganisms were isolated from inpatients clinical samples. Bacterial identification, as well as antimicrobial susceptibility levels for up to 29 antimicrobial agents and presence of Extended-Spectrum ?-Lactamases (only established in K. pneumoniae) were determined using automatic methods. Results: Of 9,918 clinical isolates, 1,917/3,777 (50.8%) [JAN/2009-JUN/2010 (Period 1)] and 4764/6141 (46.4%) [JAN/2012-DEC/2014 (Period 2)] belonged to the ESKAPE group (P <0.0001). ESKAPE were more frequent in the intensive care unit (ICU) (P <0.0001). E. faecium decreased from 5.1% to 4.1% (P <0.5), S. aureus from 10.5% to 7.0% (P <0.05), and P. aeruginosa from 12.9% to 11.6% (P <0.05), while, A. baumannii increased from 5.0% to 6.7% (P <0.05), mainly related to an increase in ICU isolates (8.4% vs. 17.1%; P <0.05). Overall, high levels of antimicrobial resistance were detected, but with few exceptions (e.g. vancomycin in E. faecium), antibiotic resistance levels remained stable or lower in Period 2. Contrarily, A. baumannii showed significantly increased resistance to different cephalosporins, carbapenems and amoxicillin plus sulbactam. Conclusion: The introduction of a successful extensively drug-resistant A. baumannii clone in the ICU is suspected. The isolation of ESKAPE and levels of antibiotic resistance levels have reduced over time. © 2021 by The Korean Society of Infectious Diseases.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.3947/IC.2021.0015
dc.identifier.scopus 2-s2.0-85115123324
dc.identifier.uri https://hdl.handle.net/20.500.12390/3001
dc.language.iso eng
dc.publisher Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS
dc.relation.ispartof Infection and Chemotherapy
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject Pseudomonas aeruginosa
dc.subject Acinetobacter baumannii es_PE
dc.subject Intensive Care Unit es_PE
dc.subject Klebsiella pneumoniae es_PE
dc.subject Multidrug resistance es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.01
dc.title Evolution of antimicrobial resistance levels of eskape microorganisms in a peruvian iv-level hospital
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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