Integrating Parasitological and Entomological Observations to Understand Malaria Transmission in Riverine Villages in the Peruvian Amazon Rosas-Aguirre, Angel es_PE Moreno, Marta es_PE Moreno-Gutierrez, Diamantina es_PE Llanos-Cuentas, Alejandro es_PE Saavedra, Marlon es_PE Contreras-Mancilla, Juan es_PE Barboza, Jose es_PE Alava, Freddy es_PE Aguirre, Kristhian es_PE Carrasco, Gabriel es_PE Prussing, Catharine es_PE Vinetz, Joseph es_PE Conn, Jan E. es_PE Speybroeck, Niko es_PE Gamboa, Dionicia es_PE 2024-05-30T23:13:38Z 2024-05-30T23:13:38Z 2021
dc.description This work was supported by the Consejo Nacional de Ciencia, Tecnologia e Innovacion Tecnologica (grant number 008-2014-FONDECYT); the Academie de Recherche et d'Enseignement Superieur-Commission de la Cooperation au Developpement of Belgium (grant number ARES-CCD, PRD-Peru 2014-2019 to N. S., A. L. C., and A. R. A.); World Health Organization Special Programme for Research and Training in Tropical Diseases (grant number 201460655 to D. G.); and National Institutes of Health, National Institute of Allergy and Infectious Diseases (grant numbers U19AI089681 to J. M. V. and R01AI110112 to J. E. C.). A. R. A. is a Postdoctoral Researcher of the Fonds de la Recherche Scientifique (FNRS, Belgium).
dc.description.abstract Background. Remote rural riverine villages account for most of the reported malaria cases in the Peruvian Amazon. As transmission decreases due to intensive standard control efforts, malaria strategies in these villages will need to be more focused and adapted to local epidemiology. Methods. By integrating parasitological, entomological, and environmental observations between January 2016 and June 2017, we provided an in-depth characterization of malaria transmission dynamics in 4 riverine villages of the Mazan district, Loreto department. Results. Despite variation across villages, malaria prevalence by polymerase chain reaction in March 2016 was high (>25% in 3 villages), caused by Plasmodium vivax mainly and composed of mostly submicroscopic infections. Housing without complete walls was the main malaria risk factor, while households close to forest edges were more commonly identified as spatial clusters of malaria prevalence. Villages in the basin of the Mazan River had a higher density of adult Anopheles darlingi mosquitoes, and retained higher prevalence and incidence rates compared to villages in the basin of the Napo River despite test-and-treat interventions. Conclusions. High heterogeneity in malaria transmission was found across and within riverine villages, resulting from interactions between the microgeographic landscape driving diverse conditions for vector development, housing structure, and human behavior.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights info:eu-repo/semantics/openAccess
dc.subject transmission
dc.subject malaria es_PE
dc.subject heterogeneity es_PE
dc.subject Amazon es_PE
dc.subject incidence es_PE
dc.subject prevalence es_PE
dc.subject human biting rate es_PE
dc.subject entomological inoculation rate es_PE
dc.subject Peru es_PE
dc.title Integrating Parasitological and Entomological Observations to Understand Malaria Transmission in Riverine Villages in the Peruvian Amazon
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication