Publicación:
Human monocyte response to Andean-native starch nanoparticles

No hay miniatura disponible
Fecha
2016-06-20
Autores
Gatto, Francesca
Troncoso, Omar P
Brunetti, Virgilio
Malvindi, Maria Ada
Pompa, Pier Paolo
Torres, Fernando G
Bardi, Giuseppe
Título de la revista
Revista ISSN
Título del volumen
Editor
Wiley
Proyectos de investigación
Unidades organizativas
Número de la revista
Abstracto
We used starches from two different Andean-native tubers to prepare nano-sized particles, and tested their ability to stimulate inflammatory reactions in human monocytes. Our data show that the release of inflammatory cytokines by monocytes can be differentially modulated by the administration of non-toxic doses of nanoparticles synthesized from the starch of the Andean sub-species Solanum tuberosum and Solanum goniocalyx. Furthermore, we observed a starch-nanoparticle-specific increase in inflammatory chemokine-dependent migration, and an up-regulation of immunoglobulin receptor CD16. Based on this preliminary study, we conclude that different potato starch nanoparticles possess specific properties that can induce immune responses and may be employed as immune modulators in the future.
Descripción
Palabras clave
Nanopartículas, Inflamación, Monocitos, Estado
Citación