Bienvenido al Repositorio Institucional del Concytec

El Repositorio Institucional del Concytec tiene como objetivo permitir el libre acceso a la producción científica institucional, optimizando su visibilidad; así mismo garantizar la preservación y conservación de la información relacionada a la ciencia, tecnología e innovación.

Display.item.jsp


Por favor, utiliza este identificador para citar o enlazar este ítem:
http://hdl.handle.net/20.500.12390/728


Título: Outcomes following severe hand foot and mouth disease: A systematic review and meta-analysis
Autor(es): Jones E. 
Pillay T.D. 
Liu F. 
Luo L. 
Bazo-Alvarez J.C.
Yuan C. 
Zhao S. 
Chen Q. 
Li Y.
Liao Q. 
Yu H. 
Rogier van Doorn H. 
Sabanathan S. 
Resumen: Background. Hand, foot and mouth disease (HFMD) caused by enterovirus A71 (EV-A71) is associated with acute neurological disease in children. This study aimed to estimate the burden of long-term sequelae and death following severe HFMD. Methods. This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015. Methods.This systematic review and meta-analysis pooled all reports from English and Chinese databases including MEDLINE and Wangfang on outbreaks of clinically diagnosed HFMD and/or laboratory-confirmed EV-A71 with at least 7 days' follow-up published between 1st January 1966 and 19th October 2015.Two independent reviewers assessed the literature.We used a random effects meta-analysis to estimate cumulative incidence of neurological sequelae or death. Studies were assessed for methodological and reporting quality. Findings. 43 studies were included in the review, and 599 children from 9 studies were included in the primary analysis. Estimated cumulative incidence of death or neurological sequelae at maximum follow up was 19.8% (95% CI:10.2%, 31.3%). Heterogeneity (Iˆ2) was 88.57%, partly accounted for by year of data collection and reporting quality of studies. Incidence by acute disease severity was 0.00% (0.00, 0.00) for grade IIa; 17.0% (7.9, 28.2) for grade IIb/III; 81.6% (65.1, 94.5) for grade IV (p = 0.00) disease.
Descripción: HRvD and SS were funded by the Wellcome Trust of Great Britain ( 089276/Z/09/Z and 106680/Z/14/Z ) and a Li Ka Shing Foundation–University of Oxford Global Health Program strategic award ( LG17 ). JCBA has been awarded a doctoral scholarship by CIENCIACTIVA, an initiative of the Peruvian National Council of Science, Technology and Technological Innovation (CONCYTEC); grant contract number 231-2015-FONDECYT. HY was supported by the National Science Fund for Distinguished Young Scholars ( No.81525023 ), the National Natural Science Foundation of China ( No. 81473031 ), the Li Ka Shing Oxford Global Health Programme ( No.B9RST00-B900.57 ).
Tema: Acute disease;ataxia;Cochrane Library;disease severity;dysphagia;Embase;Enterovirus A71;facial nerve paralysis;follow up;hand foot and mouth disease;human;incidence;intensive care;internuclear ophthalmoplegia;limb weakness;Medline;meta analysis;military service;nuclear magnetic resonance imaging;outcome assessment;priority journal;Review;systematic review;Web of Science;world health organization;animal;central nervous system disease;child;complication;disease exacerbation;Enterovirus;Enterovirus infection;hand foot and mouth disease;infant;male;preschool child;prospective study;virology;Animals;Central Nervous System Diseases;Child;Child, Preschool;Disease Progression;Enterovirus;Enterovirus Infections;Hand, Foot and Mouth Disease;Humans;Infant;Male;Prospective Studies
Editorial: W.B. Saunders Ltd
Fecha de publicación: 2018
Publicado en: European Journal of Paediatric Neurology 
Financiamiento: CONT-000231-2015-FONDECYT-DE 
Tipo de publicación: info:eu-repo/semantics/review
Identificador Handle: http://hdl.handle.net/20.500.12390/728
DOI: https://doi.org/10.1016/j.ejpn.2018.04.007
Recurso relacionado: https://www.ejpn-journal.com/article/S1090-3798(17)31752-X/fulltext
Nivel de acceso: info:eu-repo/semantics/openAccess
Colección:2.1 Estudios de doctorado y postdoctorado

Registro Dublin Core completo

Google ScholarTM

Check

Altmetric

  • Compartir este item
  • QR Code

Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons