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Effect of Punica granatum (pomegranate) on sperm production in male rats treated with lead acetate

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dc.contributor.author Leiva, KP es_PE
dc.contributor.author Rubio, J es_PE
dc.contributor.author Peralta, F es_PE
dc.contributor.author Gonzales, GF es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2011
dc.description PROCOM 2009
dc.description.abstract The present study was designed to determine whether the treatment with an ethanolic extract of pomegranate (EEP) (Punica granatum) can be useful for the treatment of the deleterious effect of lead acetate (LA) administration on sperm production in rats. The effects of EEP were compared with those of ascorbic acid (AA) that is a strong antioxidant and has been shown to reverse lead-induced damage on the reproductive system. The rats were divided into five different groups: those received distilled water (control group), LA, LA with EEP, LA with AA, and EEP alone, respectively. LA administration inhibited spermatogenesis by reducing the length of the stages related to spermiation (VII and VIII) and onset of mitosis (IX-XI). LA-treated rats also showed a reduction in epididymal sperm number and daily sperm production (DSP). Administration of EEP or AA resulted in longer VIII and IX-XI stages when compared with LA-treated rats. Moreover, EEP and AA administration reduced the deleterious effect of LA on DSP and epididymal sperm number. EEP showed an antioxidant activity similar to that of AA. EEP prevented LA-induced spermatogenic disruption in rats and its antioxidant activity could explain its capacity to reverse the damage produced by LA on spermatogenesis.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.3109/15376516.2011.555789
dc.identifier.isi 291392400008
dc.identifier.uri https://hdl.handle.net/20.500.12390/1245
dc.language.iso eng
dc.publisher Taylor & Francis Online
dc.relation.ispartof Toxicology Mechanisms and Methods
dc.rights info:eu-repo/semantics/openAccess
dc.subject producción diaria de esperma
dc.subject Actividad antioxidante es_PE
dc.subject acetato de plomo es_PE
dc.subject extracto etanólico de granada es_PE
dc.subject número de espermatozoides es_PE
dc.subject espermatogénesis es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.08
dc.title Effect of Punica granatum (pomegranate) on sperm production in male rats treated with lead acetate
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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