Publicación:
A proposal of excipients mixture for the elaboration of Na131I capsules

dc.contributor.author Alviar M. es_PE
dc.contributor.author Miranda J. es_PE
dc.contributor.author Bedregal P. es_PE
dc.date.accessioned 2024-05-30T23:13:38Z
dc.date.available 2024-05-30T23:13:38Z
dc.date.issued 2020
dc.description The authors are grateful for the financial support of the Fondo Nacional de Desarrollo Cient?fico Tecnol?gico y de Innovaci?n (FONDECYT) and to the staff of Analytical Techniques Laboratory and the Radioisotope Production Plant for their contributions.
dc.description.abstract Since the use of radioiodine for thyroid therapy in the form of an oral solution has risks associated with contamination, the need to develop suitable Na131I capsules has attracted significant attention. A series of different mass combinations of excipients was prepared using ascorbic acid, sodium thiosulphate, mannitol, maltose, magnesium sulphate, lactose, dextrose, sodium phosphate, and sucrose. These compounds were tested for their volatility and oxidation profile. Two of the excipient mixtures were selected to prepare capsules due to their high stability and low volatility. The experiments performed to evaluate a new excipients mixture are described in this manuscript. © 2020, Akadémiai Kiadó, Budapest, Hungary.
dc.description.sponsorship Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - Concytec
dc.identifier.doi https://doi.org/10.1007/s10967-020-07255-w
dc.identifier.scopus 2-s2.0-85089917933
dc.identifier.uri https://hdl.handle.net/20.500.12390/2293
dc.language.iso eng
dc.publisher Springer Science and Business Media B.V.
dc.relation.ispartof Journal of Radioanalytical and Nuclear Chemistry
dc.rights info:eu-repo/semantics/openAccess
dc.subject Thyroid therapy
dc.subject Na131I capsules es_PE
dc.subject Radioiodine capsules es_PE
dc.subject Thyroid gland es_PE
dc.subject.ocde http://purl.org/pe-repo/ocde/ford#2.04.01
dc.title A proposal of excipients mixture for the elaboration of Na131I capsules
dc.type info:eu-repo/semantics/article
dspace.entity.type Publication
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